中心体蛋白 55：肿瘤发生的新范例。

Centrosomal protein 55: A new paradigm in tumorigenesis.

机构信息

Molecular and Human Genetics Laboratory, Department of Zoology, University of Lucknow, Lucknow, Uttar Pradesh 226007, India.

出版信息

Eur J Cell Biol. 2020 Jun;99(5):151086. doi: 10.1016/j.ejcb.2020.151086. Epub 2020 May 20.

DOI:10.1016/j.ejcb.2020.151086

PMID:32646645

Abstract

Centrosomal Protein 55 (Cep55), also known as c10orf3 and FLJ10540, was initially discovered as a major player in abscission, the final stage of cytokinesis. Subsequent studies have described its role in regulating the PI3K/AKT pathway, increasing cancer cell stemness, and promoting tumor formation. Clinically, Cep55 has been found to be overexpressed in many cancer types. Cep55 overexpression has been notably associated with tumor stage, tumor aggressiveness, poor prognosis, and metastasis. The present review discusses the role of Cep55 as a crucial biomarker and model in tumorigenesis.

摘要

中心体蛋白 55（Cep55），也称为 c10orf3 和 FLJ10540，最初被发现是胞质分裂末期（有丝分裂的最后阶段）的主要参与者。随后的研究描述了其在调节 PI3K/AKT 通路、增加癌细胞干性和促进肿瘤形成中的作用。临床上，已经发现 Cep55 在许多癌症类型中过度表达。Cep55 的过度表达与肿瘤分期、肿瘤侵袭性、不良预后和转移明显相关。本综述讨论了 Cep55 作为肿瘤发生的关键生物标志物和模型的作用。