UCLA Brain Tumor Imaging Laboratory, Center for Computer Vision and Imaging Biomarkers, David Geffen School of Medicine, UCLA, Los Angeles, California.
Department of Radiological Science, David Geffen School of Medicine, UCLA, Los Angeles, California.
J Nucl Med. 2021 Mar;62(3):319-325. doi: 10.2967/jnumed.120.247411. Epub 2020 Jul 9.
Our purpose was to identify correlations between F-fluorodihydroxyphenylalanine (F-FDOPA) uptake and physiologic MRI, including relative cerebral blood volume (rCBV) and apparent diffusion coefficient (ADC), in gliomas with different molecular subtypes and to evaluate their prognostic values. Sixty-eight treatment-naïve glioma patients who underwent F-FDOPA PET and physiologic MRI were retrospectively selected (36 with isocitrate dehydrogenase wild-type [IDH], 16 with mutant 1p/19q noncodeleted [IDH], and 16 with mutant codeleted [IDH]). Fluid-attenuated inversion recovery hyperintense areas were segmented and used as regions of interest. For voxelwise and patientwise analyses, Pearson correlation coefficients ( and ) between the normalized SUV (nSUV), rCBV, and ADC were evaluated. Cox regression analysis was performed to investigate the associations between overall survival and , maximum or median nSUV, median rCBV, or median ADC. For IDH and IDH gliomas, nSUV demonstrated significant positive correlations with rCBV ( = 0.25 and 0.31, respectively; = 0.50 and 0.70, respectively) and negative correlations with ADC ( = -0.19 and -0.19, respectively; = -0.58 and -0.61, respectively) in both voxelwise and patientwise analyses. IDH gliomas demonstrated a significant positive correlation between nSUV and ADC only in voxelwise analysis ( = 0.18). In Cox regression analysis, between nSUV and rCBV (hazard ratio, 28.82) or ADC (hazard ratio, 0.085) had significant associations with overall survival for only IDH gliomas. IDH gliomas showed distinctive patterns of correlations between amino acid PET and physiologic MRI. Stronger correlations between nSUV and rCBV or ADC may result in a worse prognosis for IDH gliomas.
我们的目的是确定不同分子亚型胶质瘤中 F-氟代二羟苯丙氨酸（F-FDOPA）摄取与生理 MRI 之间的相关性，包括相对脑血容量（rCBV）和表观扩散系数（ADC），并评估它们的预后价值。回顾性选择了 68 例未经治疗的脑胶质瘤患者，他们接受了 F-FDOPA PET 和生理 MRI 检查（36 例 IDH 野生型，16 例 1p/19q 非缺失型突变 IDH，16 例 IDH 缺失型突变）。对液体衰减反转恢复高信号区域进行分割，并用作感兴趣区。进行体素和患者分析，评估归一化 SUV（nSUV）、rCBV 和 ADC 之间的 Pearson 相关系数（和）。进行 Cox 回归分析以研究总生存期与、最大或中位数 nSUV、中位数 rCBV 或中位数 ADC 之间的相关性。对于 IDH 和 IDH 胶质瘤，nSUV 与 rCBV 呈显著正相关（=0.25 和 0.31，分别；=0.50 和 0.70，分别），与 ADC 呈显著负相关（=-0.19 和-0.19，分别；=-0.58 和-0.61，分别），在体素和患者分析中均如此。仅在体素分析中，IDH 胶质瘤中 nSUV 与 ADC 之间存在显著正相关（=0.18）。在 Cox 回归分析中，nSUV 与 rCBV（危险比，28.82）或 ADC（危险比，0.085）之间的仅在 IDH 胶质瘤中与总生存期存在显著相关性。IDH 胶质瘤中氨基酸 PET 与生理 MRI 之间的相关性存在独特模式。nSUV 与 rCBV 或 ADC 之间的相关性越强，IDH 胶质瘤的预后越差。
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