Sanitary Environmental Engineering Division (SEED), and Consorzio Inter-universitario Previsione e Prevenzione dei Grandi Rischi (Cu.G.Ri.), Department of Civil Engineering, University of Salerno, Via Giovanni Paolo II, 84084, Fisciano, SA, Italy.
Department of Chemistry and Biology "Adolfo Zambelli", University of Salerno, Via Giovanni Paolo II, 84084, Fisciano, SA, Italy.
Sci Rep. 2020 Jul 9;10(1):11380. doi: 10.1038/s41598-020-68397-1.
Theranostics based on two-photon excitation of therapeutics in the NIR region is an emerging and powerful tool in cancer therapy since this radiation deeply penetrates healthy biological tissues and produces selective cell death. Aggregates of gold nanoparticles coated with glutathione corona functionalized with the dansyl chromophore (a-DG-AuNPs) were synthesized and found efficient nanodevice for applications in photothermal therapy (PTT). Actually the nanoparticle aggregation enhances the quenching of radiative excitation and the consequent conversion into heat. The a-DG-AuNPs are readily internalized in Hep G2 where the chromophore acts as both antenna and transducer of the NIR radiation under two-photons excitation, determining efficient cell ablation via photothermal effect.
基于近红外区双光子激发治疗的治疗学是癌症治疗中一种新兴且强大的工具，因为这种辐射能深入穿透健康的生物组织，并产生选择性的细胞死亡。用丹磺酰基作为发色团官能化的谷胱甘肽冠状物涂覆的金纳米粒子聚集体（a-DG-AuNPs）被合成，并被发现是用于光热疗法（PTT）的有效纳米器件。实际上，纳米粒子的聚集增强了辐射激发的猝灭，从而转化为热量。a-DG-AuNPs 很容易被 Hep G2 内化，在 Hep G2 中，发色团既作为天线又作为双光子激发下近红外辐射的换能器，通过光热效应有效地实现细胞消融。
