Stavitsky Zina H, Nguyen Colin H, Johnston James Martin
Department of Pediatrics, Oregon Health Sciences University, Portland, Oregon, USA.
Renown Children's Hospital, Reno, Nevada, USA.
Case Rep Neurol. 2020 Jun 12;12(2):210-213. doi: 10.1159/000507779. eCollection 2020 May-Aug.
Anti-N-methyl-D-aspartate receptor encephalitis (NMDARE) is an autoimmune form of encephalitis, first described in 2005 and now recognized as among the more common causes of encephalitis. While NMDARE can result in permanent neurologic deficits or even mortality, the prognosis in children is generally more favorable; 75-85% of children and teenagers achieve a full or substantial recovery. We describe here a preadolescent female, whose course of NMDARE was complicated by a unilateral stroke, resulting in permanent deficits. The imaging characteristics suggest a vascular (thrombotic) etiology. To our knowledge, this is the first report of stroke in the setting of NMDARE.
抗N-甲基-D-天冬氨酸受体脑炎（NMDARE）是一种自身免疫性脑炎，于2005年首次被描述，如今被认为是脑炎较为常见的病因之一。虽然NMDARE可导致永久性神经功能缺损甚至死亡，但儿童的预后通常更为乐观；75%至85%的儿童和青少年可实现完全或基本康复。我们在此描述一名青春期前女性，其NMDARE病程因单侧中风而复杂化，导致永久性缺损。影像学特征提示血管（血栓形成）病因。据我们所知，这是NMDARE背景下中风的首例报告。
