Spreafico G, Gadola G, Cammelli F, Caffarra P, Scaglioni A
Department of Nuclear Medicine, Legnano Hospital, USSL N. 70, Italy.
Eur J Nucl Med. 1988;14(11):565-8. doi: 10.1007/BF00286778.
A method for the relative quantification of 99mTc-HM-PAO distribution in brain SPECT is described. The method, applied in 12 normal volunteers and 150 patients suffering from different cerebral diseases, uses circumferential profiles to quantify the relative radionuclide distribution in the brain tomograms as an angular function with the origin at the center of the brain slice. Abnormal 99mTc-HM-PAO distribution is evaluated by comparing the count content of symmetrical selected parts of the profile curve and comparing each patient's profile with the corresponding limits of normal ones, determined from the pooled profiles of 12 normal subjects. This computerized method allows an accurate, reproducible and objective assessment of the relative HM-PAO distribution in the brain.
描述了一种用于脑单光子发射计算机断层扫描（SPECT）中99mTc-HM-PAO分布相对定量的方法。该方法应用于12名正常志愿者和150名患有不同脑部疾病的患者，利用圆周轮廓将脑断层图像中的放射性核素相对分布量化为以脑切片中心为原点的角度函数。通过比较轮廓曲线对称选定部分的计数含量，并将每位患者的轮廓与由12名正常受试者的汇总轮廓确定的正常轮廓相应限值进行比较，来评估99mTc-HM-PAO分布异常情况。这种计算机化方法能够对脑中HM-PAO的相对分布进行准确、可重复且客观的评估。
