Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Avenida do Café s/n - Campus da USP, Sao Paulo, 4040-904, Brazil.
Department of Orthodontics, University Medical Centre of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.
Clin Oral Investig. 2021 Mar;25(3):1307-1318. doi: 10.1007/s00784-020-03437-8. Epub 2020 Jul 9.
The present study aimed to evaluate if genetic variants in PAX9, MSX1, TGFα, FGF3, FGF10, FGF13, GLI2 and GLI3 are involved in TS of permanent teeth.
Pretreatment dental records from orthodontic patients were assessed prior to recruitment. Patients with tooth agenesis and congenital anomalies (including oral cleft) and/or syndromes were excluded. Dental casts were used to measure the maximum crown dimensions of all fully erupted permanent teeth except second and third molars in mesiodistal direction. Teeth with caries, occlusal wear, mesiodistal restorations, and obvious deformities were not evaluated. Genomic DNA samples were used for genotyping. The allelic discrimination of 13 genetic variants was performed. The associations between TS and genotype were analyzed by linear regression, adjusted by gender at a significance level of p ≤ 0.05.
Genetic polymorphisms in the tooth agenesis-related genes studied here were associated with increased and decreased TS, in both maxilla and mandible (p < 0.05).
This study reported associations of novel tooth agenesis-related gene variants with permanent tooth size variations.
The presence of some genetic variants could allow the prediction of permanent tooth size.
本研究旨在评估 PAX9、MSX1、TGFα、FGF3、FGF10、FGF13、GLI2 和 GLI3 中的遗传变异是否与恒牙迟萌有关。
在招募前评估正畸患者的预处理牙列记录。排除有牙齿缺失、先天性异常（包括口腔裂）和/或综合征的患者。使用牙模测量所有完全萌出的恒牙（除第二和第三磨牙外）的近远中向最大冠尺寸。未评估有龋齿、咬合磨损、近远中向修复体和明显畸形的牙齿。使用基因组 DNA 样本进行基因分型。对 13 个遗传变异的等位基因进行了区分。在 p 值≤0.05 的显著性水平下，通过性别对 TS 和基因型之间的关联进行线性回归分析。
研究中与牙齿缺失相关基因的遗传多态性与上颌和下颌的恒牙迟萌呈正相关和负相关（p<0.05）。
本研究报道了新的与牙齿缺失相关基因变异与恒牙大小变化之间的关联。
某些遗传变异的存在可以预测恒牙的大小。
