Manni J J, Kuijpers W, Huygen P L, Eggermont J J
Department of Otorhinolaryngology, University of Nijmegen, The Netherlands.
Hear Res. 1988 Nov;36(2-3):139-51. doi: 10.1016/0378-5955(88)90056-1.
A combined morphological and physiological study on the effect of saccus obliteration on the cochlea and the vestibular labyrinth of the rat is presented. Endolymphatic hydrops was successfully induced in 49% of the animals. It was frequently associated with fistulae of the membranous wall and degenerative changes in the organ of Corti and spiral ganglion. In hydropic ears electrocochleography revealed a CAP threshold increase only in those cases where hydrops was associated with loss of hair cells and ganglion cells. In two of these animals also an increased negative SP was present. Static otolith reflexes were found to be normal in all hydropic ears despite severe lesions of the saccule in some of these. Abnormal canal reflexes measured by electronystagmography and cupulometry were established in animals with hydrops of the semicircular canals and in one animal with a fistula of the saccule.
本文介绍了一项关于大鼠球囊闭塞对耳蜗和前庭迷路影响的形态学与生理学联合研究。49%的动物成功诱发了内淋巴积水。它常与膜壁瘘管以及柯蒂氏器和螺旋神经节的退行性变化相关。在积水耳中，耳蜗电图显示仅在积水伴有毛细胞和神经节细胞丢失的情况下，复合动作电位（CAP）阈值升高。其中两只动物还出现了负性总和电位（SP）升高。尽管部分积水耳的球囊有严重病变，但所有积水耳的静态耳石反射均正常。通过眼震电图和壶腹嵴测量法测得的异常半规管反射在半规管积水的动物以及一只球囊瘘管的动物中出现。
