CASR rs1801725 多态性与结直肠癌的风险和预后相关：一项病例对照研究。

CASR rs1801725 polymorphism is associated with the risk and prognosis of colorectal cancer: A case-control study.

机构信息

Department of Gastrointestinal Surgery, Affiliated Hospital of Jiangnan University (Wuxi Third People's Hospital), Wuxi, China.

Department of Anorectal Surgery, Nantong Third People's Hospital, Nantong University, Nantong, China.

出版信息

J Clin Lab Anal. 2020 Nov;34(11):e23463. doi: 10.1002/jcla.23463. Epub 2020 Jul 10.

DOI:10.1002/jcla.23463

PMID:32648293

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7676189/

Abstract

BACKGROUND

The extracellular calcium-sensing receptor (CASR) controls body calcium homeostasis. Increased levels of calcium are associated with protecting against colorectal cancer (CRC). This study aimed to determine the relationship between CASR gene rs1801725 polymorphism and CRC risk and prognosis.

METHODS

We conducted a hospital-based case-control study and a meta-analysis to evaluate the association of CASR gene rs1801725 polymorphism with CRC susceptibility.

RESULTS

This study proved that CASR rs1801725 polymorphism was associated with a higher risk to develop CRC (TT vs GG: OR 1.92, 95% CI [1.03-3.59], P = .042; T vs G: OR 1.30, 95% CI [1.03-1.64], P = .030). Subgroup analysis showed that this polymorphism increased the risk of CRC among smokers, and those aged ≥60 years (TT vs GG: OR 3.37, 95% CI [1.12-10.14], P = .034). We also found that this polymorphism was associated with the tumor size, TNM stage, and lymph node metastasis of CRC (GT vs GG: OR 2.03, 95% CI [1.32-3.10], P = .001). In addition, CASR gene rs1801725 polymorphism correlated with the survival of CRC patients. Further meta-analysis also obtained a significant association between this SNP and CRC risk (TT + GT vs GG: OR 1.28, 95% CI [1.01, 1.63], P = .041). Subgroup analyses by ethnicity observed a link between rs1801725 polymorphism and CRC risk in Asians, but not in Caucasians and mixed populations.

CONCLUSION

In conclusion, this case-control study and meta-analysis showed that CASR rs1801725 polymorphism increased the risk of CRC. Further studies from other races are urgently needed.

摘要

背景

细胞外钙敏感受体 (CASR) 控制着体内钙的稳态。钙水平升高与预防结直肠癌 (CRC) 有关。本研究旨在确定 CASR 基因 rs1801725 多态性与 CRC 风险和预后的关系。

方法

我们进行了一项基于医院的病例对照研究和荟萃分析，以评估 CASR 基因 rs1801725 多态性与 CRC 易感性的关系。

结果

本研究证明 CASR rs1801725 多态性与 CRC 的发病风险增加相关（TT 与 GG：OR 1.92，95%CI [1.03-3.59]，P = 0.042；T 与 G：OR 1.30，95%CI [1.03-1.64]，P = 0.030）。亚组分析表明，这种多态性增加了吸烟者和年龄≥60 岁人群发生 CRC 的风险（TT 与 GG：OR 3.37，95%CI [1.12-10.14]，P = 0.034）。我们还发现，这种多态性与 CRC 的肿瘤大小、TNM 分期和淋巴结转移有关（GT 与 GG：OR 2.03，95%CI [1.32-3.10]，P = 0.001）。此外，CASR 基因 rs1801725 多态性与 CRC 患者的生存有关。进一步的荟萃分析也发现，该 SNP 与 CRC 风险之间存在显著关联（TT+GT 与 GG：OR 1.28，95%CI [1.01, 1.63]，P = 0.041）。按种族进行的亚组分析表明，rs1801725 多态性与亚洲人群 CRC 风险之间存在关联，但在白人和混合人群中则没有。