Li Zhan-Zhan, Shen Liang-Fang, Li Yan-Yan, Chen Peng, Chen Li-Zhang
Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China.
Department of Nursing, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China.
Oncotarget. 2016 Sep 6;7(36):58569-58578. doi: 10.18632/oncotarget.10707.
A meta-analysis was performed to evaluate the diagnostic value of miR-378 for detecting human cancers. Systematic electronic searches were conducted in PubMed, Web of Science, Embase, China National Knowledge Infrastructure, and Wanfang from the inception to January 15, 2016. We used the bivariate mixed effects models to estimate the combined sensitivity, specificity, PLRs (positive likelihood ratios), NLR (negative likelihood ratios), DORs (diagnostic odds ratios) and their 95% CI (confidence intervals) for assessing the diagnostic performance of miR-378 for cancers. Twelve studies were included in the meta-analysis, with a total number of 1172 cancer patients and 809 health controls. The overall estimated sensitivity and specificity were 0.75 and 0.74. The pooled PLR was 2.91, NLR was 0.34, DOR was 8.50, and AUC (Area Under the Curve) was 0.81. The subgroup analyses suggested that AUC for plasma-based is higher than serum-based. The overall diagnostic values of miR-378 in the present meta-analyses are moderate accurate for human cancers; The source of specimen has an effect on the diagnostic accuracy. The diagnostic value of serum-based was higher than that of plasma-based.
进行了一项荟萃分析以评估miR-378在检测人类癌症中的诊断价值。从数据库建库至2016年1月15日，在PubMed、Web of Science、Embase、中国知网和万方数据库中进行了系统的电子检索。我们使用双变量混合效应模型来估计合并敏感性、特异性、阳性似然比（PLR）、阴性似然比（NLR）、诊断比值比（DOR）及其95%置信区间（CI），以评估miR-378对癌症的诊断性能。荟萃分析纳入了12项研究，共有1172例癌症患者和809例健康对照。总体估计敏感性和特异性分别为0.75和0.74。合并PLR为2.91，NLR为0.34，DOR为8.50，曲线下面积（AUC）为0.81。亚组分析表明，基于血浆的AUC高于基于血清的。在本荟萃分析中，miR-378对人类癌症的总体诊断价值具有中等准确性；样本来源对诊断准确性有影响。基于血清的诊断价值高于基于血浆的。
