Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, U.S.A.
Clin Sci (Lond). 2020 Jul 17;134(13):1697-1714. doi: 10.1042/CS20200050.
Acute influenza virus infections are a global public health concern accounting for millions of illnesses worldwide ranging from mild to severe with, at time, severe complications. Once an individual is infected, the immune system is triggered in response to the pathogen. This immune response can be beneficial ultimately leading to the clearance of the viral infection and establishment of immune memory mechanisms. However, it can be detrimental by increasing susceptibility to secondary bacterial infections and resulting in permanent changes to the lung architecture, in the form of fibrotic sequelae. Here, we review influenza associated bacterial super-infection, the formation of T-cell memory, and persistent lung injury resulting from influenza infection.
急性流感病毒感染是一个全球性的公共卫生关注点，导致了全球数百万人患病，从轻度到重度，有时还伴有严重并发症。一旦个体感染，免疫系统就会对病原体做出反应。这种免疫反应可能是有益的，最终导致病毒感染的清除和免疫记忆机制的建立。然而，它也可能有害，增加了继发细菌感染的易感性，并导致肺结构的永久性改变，形成纤维性后遗症。在这里，我们回顾了流感相关的细菌重感染、T 细胞记忆的形成以及流感感染导致的持续性肺损伤。
