血清可溶性 B7-H4 在急性胰腺炎中的预测价值。
Predictive value of serum soluble B7-H4 in acute pancreatitis.
机构信息
Department Hepatobiliary & Pancreat Surgery, Zhongnan Hospital, Wuhan University, Wuhan, China.
Department Neurology, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
出版信息
Eur J Clin Invest. 2020 Dec;50(12):e13346. doi: 10.1111/eci.13346. Epub 2020 Aug 11.
BACKGROUND
Studies reported that soluble B7-H4 (sB7-H4) was significantly related to the progression and prognosis of inflammatory diseases, and whether sB7-H4 is related to the severity and prognosis of acute pancreatitis (AP) timely has not been reported.
MATERIALS AND METHODS
Clinical database data of 446 AP patients were retrospectively collected, and the correlation between the expression serum levels of sB7-H4 with inflammatory factors and prognostic scores was analysed in AP patients.
RESULTS
Soluble B7-H4 was significantly correlated with IL-6, IL-8, TNF-α, PCT, CRP levels and WBC count (P < .01), with correlation coefficients of R = .61, .53, .46, .60, .57 and .47, respectively, and AUCs were 0.905, 0.837, 0.797, 0.858, 0.890, 0.841 and 0.855, respectively. In addition, sB7-H4 was significantly correlated with the Ranson score, APACHE II score and BISAP score (P < .001), with correlation coefficients of R = .58, .63 and .59, respectively. The AUCs of assessing local complications of AP were 0.908, 0.863, 0.785 and 0.844, respectively; assessing organ failure were 0.872, 0.790, 0.796 and 0.857, respectively; and assessing in-hospital mortality were 0.839, 0.821, 0.796 and 0.823, respectively.
CONCLUSIONS
Soluble B7-H4 could be used as a marker for the diagnosis, severity assessment and poor prognosis assessment of AP patients, which may have potential clinical applications.
背景
有研究报道可溶性 B7-H4（sB7-H4）与炎症性疾病的进展和预后显著相关，而 sB7-H4 是否与急性胰腺炎（AP）的严重程度和预后相关尚未见报道。
材料和方法
回顾性收集 446 例 AP 患者的临床数据库资料，分析 AP 患者血清 sB7-H4 表达水平与炎症因子和预后评分的相关性。
结果
可溶性 B7-H4 与 IL-6、IL-8、TNF-α、PCT、CRP 水平和白细胞计数呈显著正相关（P<0.01），相关系数 R 分别为 0.61、0.53、0.46、0.60、0.57 和 0.47，AUC 分别为 0.905、0.837、0.797、0.858、0.890、0.841 和 0.855。此外，sB7-H4 与 Ranson 评分、APACHE II 评分和 BISAP 评分显著相关（P<0.001），相关系数 R 分别为 0.58、0.63 和 0.59。评估 AP 局部并发症的 AUC 分别为 0.908、0.863、0.785 和 0.844；评估器官衰竭的 AUC 分别为 0.872、0.790、0.796 和 0.857；评估住院死亡率的 AUC 分别为 0.839、0.821、0.796 和 0.823。
结论
可溶性 B7-H4 可作为评估 AP 患者诊断、严重程度和预后不良的标志物，具有潜在的临床应用价值。
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