Johns Hopkins University School of Medicine, the Division of Gynecologic Pathology, Department of Pathology, Johns Hopkins Medicine, and the Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, Maryland.
Obstet Gynecol. 2020 Aug;136(2):365-368. doi: 10.1097/AOG.0000000000003908.
Morcellation at the time of minimally invasive hysterectomy or myomectomy for presumed benign indications carries a risk of disseminating undiagnosed uterine malignancies.
A 57-year-old woman with a remote history of laparoscopic hysterectomy with morcellation of a cellular leiomyoma presented with a newly diagnosed complex pelvic mass. Owing to adherence of the mass to the rectum and numerous peritoneal tumor implants, a surgical cytoreductive procedure was performed. The pelvic mass, implants, and original hysterectomy specimen were histologically identical and consistent with low-grade endometrial stromal sarcoma. Owing to lack of tumor-myometrial interface on the original morcellated specimen, this malignant diagnosis was not made at the time of hysterectomy.
Morcellation of the uterus can hinder an accurate pathologic diagnosis of uterine stromal neoplasms.
在微创子宫切除术或子宫肌瘤切除术时进行分碎术,用于疑似良性指征,会有传播未诊断的子宫恶性肿瘤的风险。
一位 57 岁的妇女,既往有腹腔镜子宫切除术的病史,术中对一个细胞性平滑肌瘤进行了分碎术,现在出现了新诊断的复杂盆腔肿块。由于肿块与直肠粘连,且有许多腹膜肿瘤种植,因此进行了手术减瘤术。盆腔肿块、种植物和原始子宫切除术标本在组织学上是相同的,符合低级别子宫内膜间质肉瘤。由于原始分碎标本上没有肿瘤-子宫肌层界面,因此在子宫切除术时没有做出恶性诊断。
子宫的分碎术可能会阻碍对子宫间质肿瘤的准确病理诊断。