Duperval R, Hermans P E, Brewer N S, Roberts G D
Chest. 1977 Jul;72(1):13-9. doi: 10.1378/chest.72.1.13.
Cryptococcus neoformans was isolated from 65 patients: 11 had meningitis, 11 had disseminated cryptococcosis without meningitis, and 43 had C neoformans isolated from the respiratory tract. Predisposing conditions and the diagnostic value of cultures from various sites and of the latex agglutination test on cerebrospinal fluid and serum are analyzed for patients with extrapulmonary disease. Nine patients had pleural effusions; the effusion was cultured in six and yielded C neoformans in four. None of 11 deaths among 43 patients with respiratory tract isolates could be attributed to cryptococosis. The 32 survivors were nor treated with antifungal agents. Twenty-six of 43 patients with respiratory isolates had various bronchopulmonary disorders, with chronic obstructive pulmonary diseases and asthma the most common (28 percent). Seven of 28 patients (25 percent) with roentgenographically detected lung lesions had carcinoma of the lung. Roentgenographic evidence of a lung lesion and C neoformans grown from the respiratory tract warrant a further search for carcinoma of the lung.
从65例患者中分离出新型隐球菌：11例患有脑膜炎，11例患有无脑膜炎的播散性隐球菌病，43例从呼吸道分离出新型隐球菌。分析了肺外疾病患者的易感因素以及来自不同部位的培养物和脑脊液及血清乳胶凝集试验的诊断价值。9例患者有胸腔积液；6例对积液进行了培养，4例培养出新型隐球菌。43例呼吸道分离株患者中有11例死亡，无一例死亡可归因于隐球菌病。32名幸存者未接受抗真菌药物治疗。43例呼吸道分离株患者中有26例患有各种支气管肺部疾病，其中慢性阻塞性肺疾病和哮喘最为常见（28%）。28例经X线检查发现肺部病变的患者中有7例（25%）患有肺癌。肺部病变的X线证据和从呼吸道培养出新型隐球菌提示需进一步排查肺癌。
