Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, United States.
Department of Surgery, Memorial Sloan Kettering Cancer Center, United States.
Oral Oncol. 2020 Nov;110:104879. doi: 10.1016/j.oraloncology.2020.104879. Epub 2020 Jul 7.
Proton therapy has recently gained substantial momentum worldwide due to improved accessibility to the technology and sustained interests in its advantage of better tissue sparing compared to traditional photon radiation. Proton therapy in head and neck cancer has a unique advantage given the complex anatomy and proximity of targets to vital organs. As head and neck cancer patients are living longer due to epidemiological shifts and advances in treatment options, long-term toxicity from radiation treatment has become a major concern that may be better mitigated by proton therapy. With increased utilization of proton therapy, new proton centers breaking ground, and as excitement about the technology continue to increase, we aim to comprehensively review the evidence of proton therapy in major subsites within the head and neck, hoping to facilitate a greater understanding of the full risks and benefits of proton therapy for head and neck cancer.
由于质子治疗技术的普及和人们对其与传统光子放疗相比具有更好的组织保护优势的持续关注，近年来，质子治疗在全球范围内得到了迅猛发展。由于头颈部肿瘤的解剖结构复杂，且治疗靶区与重要器官毗邻，因此质子治疗具有独特的优势。随着流行病学变化和治疗选择的进步，头颈部癌症患者的生存期延长，放疗的长期毒性已成为一个主要问题，质子治疗可能对此有更好的缓解效果。随着质子治疗的应用增加，新的质子中心开始建设，人们对该技术的兴趣不断增加，我们旨在全面回顾质子治疗在头颈部主要亚部位的证据，希望有助于更全面地了解质子治疗对头颈部癌症的全部风险和获益。
