接受冠状动脉搭桥手术患者的主动脉内膜脂质含量和血清脂蛋白与临床预后的关系。

Aortic intimal lipid content and serum lipoproteins in patients undergoing coronary by-pass surgery as related to clinical prognosis.

作者信息

Bondjers G, Lindén T, Fager G, Olofsson S O, Olsson G, Wiklund O

机构信息

Department of Medicine I, University of Göteborg, Sweden.

出版信息

Atherosclerosis. 1988 Aug;72(2-3):231-9. doi: 10.1016/0021-9150(88)90085-8.

DOI:10.1016/0021-9150(88)90085-8

PMID:3265059

Abstract

Intimal lipid concentrations were determined in aortic biopsies obtained during coronary by-pass surgery. In addition serum lipoprotein and apolipoprotein levels were quantitated and their relationships to aortic intimal lipid concentrations were analysed. The possibility to use aortic intimal lipid and serum lipoprotein or apolipoprotein concentrations to predict clinical prognosis following the coronary by-pass operation was also evaluated. Intimal cholesterol, cholesterol ester, phosphatidylcholine and sphingomyelin were intercorrelated, whereas none of these lipid fractions correlated to aortic intimal triglyceride levels. Patients with hypertension had higher aortic intimal cholesterol ester levels than normotensive patients. There was a positive correlation between the number of stenosed coronary arteries and serum apo B or triglyceride levels. In addition there was a negative correlation between the number of stenosed arteries and HDL-cholesterol. Prognosis after the operation was inversely correlated to serum apo A-I levels. Our data do not, however, support the notion that aortic intimal lipid levels can be used to evaluate prognosis after coronary by-pass surgery.

摘要

在冠状动脉搭桥手术期间获取的主动脉活检组织中测定内膜脂质浓度。此外，对血清脂蛋白和载脂蛋白水平进行定量，并分析它们与主动脉内膜脂质浓度的关系。还评估了使用主动脉内膜脂质以及血清脂蛋白或载脂蛋白浓度来预测冠状动脉搭桥手术后临床预后的可能性。内膜胆固醇、胆固醇酯、磷脂酰胆碱和鞘磷脂相互关联，而这些脂质组分均与主动脉内膜甘油三酯水平无关。高血压患者的主动脉内膜胆固醇酯水平高于血压正常的患者。狭窄冠状动脉的数量与血清载脂蛋白B或甘油三酯水平呈正相关。此外，狭窄动脉的数量与高密度脂蛋白胆固醇呈负相关。手术后的预后与血清载脂蛋白A-I水平呈负相关。然而，我们的数据并不支持主动脉内膜脂质水平可用于评估冠状动脉搭桥手术后预后的观点。