Averna M R, Barbagallo C M, Di Paola G, Labisi M, Pinna G, Marino G, Dimita U, Notarbartolo A
Istituto di Medicina Interna e Geriatria, Università di Palermo, Italia.
Biol Neonate. 1991;60(3-4):187-92. doi: 10.1159/000243407.
In this study lipid and apolipoprotein patterns were investigated at birth and compared with those of adults. In cord sera, cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol were 38.2, 46.2, 50.5, and 31.9%, respectively, of adult values. Apolipoprotein AII, B and CIII were 48.6, 30.6 and 44.5% of adult values, while apo AI, apo CII and apo E showed values approaching those of adults (63.4, 73.3 and 89.7%, respectively). Also cholesterol/HDL cholesterol and LDL cholesterol/HDL cholesterol ratios were lower in newborns. In cord sera, lipids were correlated with various apolipoproteins in a surprisingly different way from adult sera. HDL cholesterol was not inversely correlated with triglycerides, and showed a highly positive correlation with apo E, apo CII and apo CIII, which did not correlate with HDL cholesterol in adults. These data supported the presence of significant differences in plasma concentrations and composition of lipoproteins at birth. Therefore HDL, apo CII, and apo E seem to play a different and more important metabolic role in neonatal lipid metabolism.
在本研究中，对出生时的脂质和载脂蛋白模式进行了调查，并与成年人的模式进行了比较。在脐血血清中，胆固醇、甘油三酯、低密度脂蛋白（LDL）胆固醇和高密度脂蛋白（HDL）胆固醇分别为成人值的38.2%、46.2%、50.5%和31.9%。载脂蛋白AII、B和CIII分别为成人值的48.6%、30.6%和44.5%，而载脂蛋白AI、载脂蛋白CII和载脂蛋白E的值接近成年人的值（分别为63.4%、73.3%和89.7%）。新生儿的胆固醇/HDL胆固醇和LDL胆固醇/HDL胆固醇比值也较低。在脐血血清中，脂质与各种载脂蛋白的相关性与成人血清中的方式惊人地不同。HDL胆固醇与甘油三酯无负相关，与载脂蛋白E、载脂蛋白CII和载脂蛋白CIII呈高度正相关，而这些在成年人中与HDL胆固醇无相关性。这些数据支持出生时血浆脂蛋白浓度和组成存在显著差异。因此，HDL、载脂蛋白CII和载脂蛋白E似乎在新生儿脂质代谢中发挥着不同且更重要的代谢作用。
