Jenabi E, Poorolajal J
Department of Midwifery, Toyserkan Branch, Islamic Azad University, Toyserkan, Iran.
Modeling of Noncommunicable Diseases Research Center, Department of Epidemiology & Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
Public Health. 2015 Jul;129(7):872-80. doi: 10.1016/j.puhe.2015.04.017. Epub 2015 May 27.
Several epidemiological studies have investigated the association between body mass index (BMI) and endometrial cancer in recent years. This up-to-date meta-analysis was conducted to obtain an overall effect estimate based on current evidence.
A meta-analysis was conducted until March 2015.
Major electronic databases including PubMed, Web of Science, and Scopus were searched. The reference lists and related scientific conference databases were searched for additional data. Cohort and case-control studies addressing the association between BMI and endometrial cancer were included. The exposure of interest was overweight and obesity. The outcome of interest was endometrial cancer of any type confirmed pathologically. The effect measure of choice was rate ratio (RR) for cohort studies and odds ratio (OR) for case-control studies. The random effect model was reported.
Of 6241 retrieved references, 40 studies were included in the meta-analysis including 20 prospective cohort studies and 20 case-control studies involving 32,281,242 participants. The results of both cohort and case-control studies showed a significant association. Based on random effect model, compared to normal weight people, the estimated RR and OR of endometrial cancer was 1.34 (95% CI: 1.20, 1.48) and 1.43 (95% CI: 1.30, 1.56) for the overweight and 2.54 (95% CI: 2.27, 2.81) and 3.33 (95% CI: 2.87, 3.79) for the obese, respectively.
The results of this meta-analysis indicated that BMI is strongly associated with an increased risk of endometrial cancer. Further investigations are required to expect the pathophysiology of the endometrial cancer caused by overweight and obesity.
近年来，多项流行病学研究调查了体重指数（BMI）与子宫内膜癌之间的关联。本项最新的荟萃分析旨在根据现有证据得出总体效应估计值。
截至2015年3月进行了一项荟萃分析。
检索了包括PubMed、科学网和Scopus在内的主要电子数据库。还检索了参考文献列表和相关科学会议数据库以获取更多数据。纳入了探讨BMI与子宫内膜癌之间关联的队列研究和病例对照研究。感兴趣的暴露因素为超重和肥胖。感兴趣的结局为经病理证实的任何类型的子宫内膜癌。队列研究的效应测量指标为率比（RR），病例对照研究的效应测量指标为比值比（OR）。报告采用随机效应模型。
在检索到的6241篇参考文献中，有40项研究纳入了荟萃分析，包括20项前瞻性队列研究和20项病例对照研究，涉及32281242名参与者。队列研究和病例对照研究的结果均显示存在显著关联。基于随机效应模型，与正常体重者相比，超重者患子宫内膜癌的估计RR和OR分别为1.34（95%CI：1.20，1.48）和1.43（95%CI：1.30，1.56），肥胖者分别为2.54（95%CI：2.27，2.81）和3.33（95%CI：2.87，3.79）。
本荟萃分析结果表明，BMI与子宫内膜癌风险增加密切相关。需要进一步研究以了解超重和肥胖导致子宫内膜癌的病理生理学机制。
