Rollema H, Booth R G, Castagnoli N
Department of Pharmaceutical Chemistry, University of California, San Francisco 94143.
Eur J Pharmacol. 1988 Aug 9;153(1):131-4. doi: 10.1016/0014-2999(88)90597-3.
The MPP+-like neurotoxicity of the 2-methyl-beta-carbolinium species, a possible endogenous condensation product structurally related to MPP+, has been assessed by an intracerebral microdialysis technique. Although much less potent, this compound appears to cause the selective and irreversible destruction of nigrostriatal nerve terminals in rat brain in a manner similar to that observed under comparable conditions with MPP+.
2-甲基-β-咔啉鎓类物质是一种可能的内源性缩合产物，其结构与MPP⁺相关，通过脑内微透析技术评估了其类MPP⁺神经毒性。尽管该化合物的效力要低得多，但它似乎以类似于在与MPP⁺相当的条件下观察到的方式，导致大鼠脑内黑质纹状体神经末梢的选择性和不可逆破坏。
