肌球蛋白-7 的一条新轻链。
A new light chain for myosin-7.
机构信息
Dept. of Cell Biology and Physiology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
Dept. of Cell Biology and Physiology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
出版信息
J Biol Chem. 2020 Jul 10;295(28):9297-9298. doi: 10.1074/jbc.H120.014595.
Recent research has revealed that an adhesion complex based on cadherins and the motor protein myosin-7b (MYO7B) links the tips of intestinal microvilli. Choi now report that a largely uncharacterized protein known as calmodulin-like protein 4 (CALML4) is a component of this adhesion complex and functions as a light chain for myosin-7b. Because the intermicrovillar adhesion complex is homologous to the myosin-7a (MYO7A)-based Usher syndrome complex and Choi also report that CALML4 can bind to myosin-7a, this work also has important implications for research on myosin-7a and hereditary deaf-blindness.
最近的研究表明，一种基于钙黏蛋白和肌球蛋白-7b（MYO7B）的黏附复合物将肠微绒毛的尖端连接起来。Choi 现在报告说，一种被称为钙调蛋白样蛋白 4（CALML4）的大部分未被表征的蛋白是该黏附复合物的一个组成部分，并作为肌球蛋白-7b 的轻链发挥作用。由于细胞间微绒毛黏附复合物与基于肌球蛋白-7a（MYO7A）的Usher 综合征复合物同源，并且 Choi 还报告说 CALML4 可以与肌球蛋白-7a 结合，因此这项工作对于肌球蛋白-7a 和遗传性耳聋-失明的研究也具有重要意义。
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