Buzzelli G, Chiarantini E, Cotrozzi G, Relli P, Matassi L, Romanelli R G, Gentilini P
Istituto di Clinica Medica Generale e Terapia Medica II, Università degli Studi di Firenze, Italy.
Liver. 1988 Dec;8(6):354-9. doi: 10.1111/j.1600-0676.1988.tb01016.x.
In patients with chronic liver disease, the reliability of various criteria generally used to diagnose impaired glucose tolerance and diabetes was evaluated. Twenty-one patients with chronic persistent hepatitis, 68 patients with chronic active hepatitis and 57 patients with liver cirrhosis were studied. All subjects underwent an oral glucose tolerance test (75 g). Impaired glucose tolerance and diabetes were diagnosed according to the criteria established by: the National Diabetes Study Group; Fajans and Conn; the European Diabetes Study Group; Deutsche Diabetes Gesellschaft; Kobberling & Creutzfeld criteria 1 and 2; Wilkerson; and the University Group Diabetes Program. The results obtained are in partial agreement with other reported data, showing a high prevalence of both impaired glucose tolerance and diabetes in chronic liver disease, with a positive correlation to the severity of hepatic involvement. However, our results show that the agreement among the criteria most frequently used for diagnosing impaired glucose tolerance and diabetes is still far from satisfactory.
对慢性肝病患者中通常用于诊断糖耐量受损和糖尿病的各种标准的可靠性进行了评估。研究了21例慢性持续性肝炎患者、68例慢性活动性肝炎患者和57例肝硬化患者。所有受试者均接受了口服葡萄糖耐量试验（75克）。根据以下机构制定的标准诊断糖耐量受损和糖尿病：国家糖尿病研究组；法扬斯和康恩；欧洲糖尿病研究组；德国糖尿病协会；科伯林和克罗伊茨费尔德标准1和标准2；威尔克森；以及大学组糖尿病计划。所得结果与其他报道的数据部分一致，显示慢性肝病中糖耐量受损和糖尿病的患病率均较高，且与肝脏受累的严重程度呈正相关。然而，我们的结果表明，最常用于诊断糖耐量受损和糖尿病的标准之间的一致性仍远不能令人满意。
