Nwose Ezekiel Uba, Obianke Joshua, Richards Ross Stuart, Bwitit Phillip Tederera, Igumbor Eunice Obiajuru
Charles Sturt University, Australia.
Acta Biomed. 2019 Jan 22;90(1):97-103. doi: 10.23750/abm.v90i1.6576.
The vulnerability of older adults to diabetes and cardiovascular complications is a global concern. Hepatorenal pathophysiology is implicated in these complications, but has yet to be clearly established, especially from rural low-mid income countries. This study investigates differences in prevalence of diabetes in aging groups and correlations of age with hepatorenal variables.
203 participants of both sexes above the age of 18 years underwent anthropometric measurements at Catholic Hospital, Abbi, Nigeria. Questionnaires collected demographic information and medical history. Urinalysis as well as routine liver and renal function tests were performed. Data analysis included determination of levels of hepatorenal abnormalities and prevalence of diseases in age groups. Percentage of disease subpopulations made up by each age-group was also determined as well as Pearson's correlation coefficient between age and hepatorenal variables, and comparison of average age and hepatorenal variables in disease subgroups.
Percentage hepatorenal abnormalities are not significantly different between age-groups. There is no significant difference in percentage level of disease between groups, but in age-groups constituting disease sub-populations (p<0.00001). The apparently healthy subpopulation comprises of younger adults compared to older adults constituting diabetes and hypertension (p < 0…). Age shows moderate correlation with renal function parameters, especially urea and chloride (r = 0.42), but relatively insignificant with liver function variables.
This report affirms that diabetes cardiovascular co-morbidity comes with aging. It also indicates that renal pathophysiology may be more associated, than liver, functions in the vulnerability of adults.
老年人易患糖尿病和心血管并发症是一个全球性问题。肝肾病理生理学与这些并发症有关，但尚未明确确立，尤其是在农村低收入和中等收入国家。本研究调查了老年人群中糖尿病患病率的差异以及年龄与肝肾变量的相关性。
203名18岁以上的男女参与者在尼日利亚阿比的天主教医院接受了人体测量。通过问卷调查收集了人口统计学信息和病史。进行了尿液分析以及常规肝肾功能测试。数据分析包括确定肝肾异常水平和各年龄组疾病的患病率。还确定了每个年龄组在疾病亚群中所占的百分比，以及年龄与肝肾变量之间的皮尔逊相关系数，并比较了疾病亚组中的平均年龄和肝肾变量。
各年龄组之间肝肾异常的百分比没有显著差异。各组之间疾病的百分比水平没有显著差异，但在构成疾病亚群的年龄组中存在显著差异（p<0.00001）。与构成糖尿病和高血压的老年人相比，明显健康的亚群由年轻人组成（p<0…）。年龄与肾功能参数，尤其是尿素和氯化物呈中度相关（r = 0.42），但与肝功能变量的相关性相对较小。
本报告证实糖尿病心血管合并症与衰老有关。它还表明，在成年人的易感性方面，肾脏病理生理学可能比肝脏功能更相关。
