糖尿病、癌症与植物化学疗法中的糖基化终产物。
Advanced glycation end products in diabetes, cancer and phytochemical therapy.
机构信息
Department of Biosciences and Biotechnology, Banasthali University, Banasthali, Rajasthan 304022, India.
Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.
出版信息
Drug Discov Today. 2020 Sep;25(9):1614-1623. doi: 10.1016/j.drudis.2020.07.003. Epub 2020 Jul 8.
The irreversible glycation and oxidation of proteins and lipids produces advanced glycation end products (AGEs). These modified AGEs are triggered to bind the receptor for AGE (RAGE), thereby activating its downstream signaling pathways, such as nuclear factor (NF)-κB and phosphoinositide 3-kinase (PI3K)/Akt, ultimately leading to diabetes and cancers. In this review, we focus on the interaction of AGE-RAGE and their associated pathways. We also consider the activity of phytochemicals, such as genistein and curcumin, that trap dicarbonyl compounds including methylglyoxal (MG) and glyoxalase that arise from multiple pathways to block AGE formation and prevent its interaction with RAGE.
蛋白质和脂质的不可逆糖化和氧化会产生晚期糖基化终产物 (AGEs)。这些经过修饰的 AGE 会被触发与 AGE 受体 (RAGE) 结合，从而激活其下游信号通路，如核因子 (NF)-κB 和磷酸肌醇 3-激酶 (PI3K)/Akt，最终导致糖尿病和癌症。在这篇综述中，我们重点关注 AGE-RAGE 的相互作用及其相关途径。我们还考虑了植物化学物质的活性，如染料木黄酮和姜黄素，它们可以捕获包括甲基乙二醛 (MG) 和甘油醛在内的二羰基化合物，这些化合物来自多个途径，可以阻止 AGE 的形成并防止其与 RAGE 相互作用。
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