College of Pharmacy, Gachon University, No. 191, Hambakmoero, Yeonsu-gu, 21936, Inchon, Korea.
Molecular and Cellular Physiology Laboratory, Department of Life Science, University of Seoul, 163 Seoulsiripdaero, Dongdaemun-gu, Seoul, 02504, Korea.
Arch Pharm Res. 2021 Apr;44(4):378-401. doi: 10.1007/s12272-021-01323-9. Epub 2021 Apr 9.
The role of advanced glycation end products (AGEs) is not limited to diabetes and diabetes-related complications. There are multiple modulators, including the receptor for advanced glycation end products, high mobility group box 1, glyoxalase 1, nuclear factor-kappa B, tumor necrosis factor-α, chronic unpredictable stress, reactive oxygen species, and inflammatory cytokines, which interact with AGE signaling and control diabetes, modulating these interacting modulators. The progression of diabetes, as well as related complications, can be controlled and treated. Natural products rich in bioactive constituents can interact with AGEs and their related mediators through various signaling cascades, thereby controlling and preventing the progression of diabetes. This review provides a deeper assessment of the signaling pathway, interactions between phytochemicals and AGEs, and its mediators, to develop a multifold therapeutic approach to prevent and treat diabetes and its related complications.
晚期糖基化终产物（AGEs）的作用不仅限于糖尿病及其相关并发症。有多种调节剂，包括晚期糖基化终产物受体、高迁移率族蛋白 1、糖氧还蛋白 1、核因子-κB、肿瘤坏死因子-α、慢性不可预测应激、活性氧和炎症细胞因子，它们与 AGE 信号相互作用并控制糖尿病，调节这些相互作用的调节剂。糖尿病及其相关并发症的进展可以得到控制和治疗。富含生物活性成分的天然产物可以通过各种信号级联与 AGE 及其相关介质相互作用，从而控制和预防糖尿病的进展。本综述更深入地评估了信号通路、植物化学物质与 AGE 及其介质之间的相互作用，以开发一种多方面的治疗方法，预防和治疗糖尿病及其相关并发症。
