结核合并症的斑马鱼模型和 HIF 激活干预的影响。
A zebrafish model of tuberculosis comorbidity and the effects of HIF-activating intervention.
机构信息
The University of Sydney, Tuberculosis Research Program at the Centenary Institute, Camperdown, NSW, Australia.
The University of Sydney, Faculty of Medicine and Health & Marie Bashir Institute, Camperdown, NSW, Australia.
出版信息
FEBS J. 2020 Sep;287(18):3917-3920. doi: 10.1111/febs.15463. Epub 2020 Jul 11.
Comorbidities are an important factor in tuberculosis pathophysiology and treatment but are understudied in animal models. Schild et al. present a zebrafish model of Mycobacterium marinum infection and wound comorbidity that retains responsiveness to protective hypoxia-inducible factor-1α activation as an example of a host-directed therapy. This platform is a new paradigm for the zebrafish-M. marinum infection model and provides a blueprint to test therapeutic interventions on infection and comorbid pathologies. Comment on: https://doi.org/10.1111/febs.15433.
合并症是结核病发病机制和治疗中的一个重要因素，但在动物模型中研究不足。Schild 等人提出了一种斑马鱼感染分枝杆菌和伤口合并症的模型，该模型保留了对保护性缺氧诱导因子-1α激活的反应性，可作为宿主导向治疗的一个例子。该平台是斑马鱼-分枝杆菌感染模型的一个新范例，为测试感染和合并病理的治疗干预措施提供了蓝图。评论见：https://doi.org/10.1111/febs.15433。
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