Johansen Matt D, Kasparian Joshua A, Hortle Elinor, Britton Warwick J, Purdie Auriol C, Oehlers Stefan H
Tuberculosis Research Program, Centenary Institute, University of Sydney, Camperdown, NSW, Australia; Sydney School of Veterinary Science, Faculty of Science, University of Sydney, Camden, NSW, Australia.
Tuberculosis Research Program, Centenary Institute, University of Sydney, Camperdown, NSW, Australia.
Dev Comp Immunol. 2018 Nov;88:169-172. doi: 10.1016/j.dci.2018.07.022. Epub 2018 Jul 21.
Host lipid metabolism is an important target for subversion by pathogenic mycobacteria such as Mycobacterium tuberculosis. The appearance of foam cells within the granuloma are well-characterised effects of chronic tuberculosis. The zebrafish-Mycobacterium marinum infection model recapitulates many aspects of human-M. tuberculosis infection and is used as a model to investigate the structural components of the mycobacterial granuloma. Here, we demonstrate that the zebrafish-M. marinum granuloma contains foam cells and that the transdifferentiation of macrophages into foam cells is driven by the mycobacterial ESX1 pathogenicity locus. This report demonstrates conservation of an important aspect of mycobacterial infection across species.
宿主脂质代谢是结核分枝杆菌等致病性分枝杆菌进行颠覆的重要靶点。肉芽肿内泡沫细胞的出现是慢性结核病的典型特征。斑马鱼-海分枝杆菌感染模型概括了人类-结核分枝杆菌感染的许多方面，并被用作研究分枝杆菌肉芽肿结构成分的模型。在这里，我们证明斑马鱼-海分枝杆菌肉芽肿含有泡沫细胞，并且巨噬细胞向泡沫细胞的转分化是由分枝杆菌ESX1致病位点驱动的。本报告证明了分枝杆菌感染的一个重要方面在物种间具有保守性。
