Gehanno P, Simonet M, Veron P
Service d'Oto-Rhino-Laryngologie et de Chirurgie Cervic-Faciale de l'Hôpital Claude-Bernard, Paris.
Ann Otolaryngol Chir Cervicofac. 1988;105(7):559-63.
After presenting the methodology of their study and the structure of their chain of swabs, the authors report the bacteriological results and therapeutic consequences which they imply. In this study, which was conducted in children between the ages of 3 months and 3 years, Haemophilus influenzae was the bacterium most frequently isolated, regardless of the age-group. It was followed by Streptococcus pneumoniae and Staphylococcus aureus. Neither the recurrent nature of the otitis nor the child's life style influenced the predominance of Haemophilus influenzae. 23% of the strains were beta-lactamase producers. The production of beta-lactamase prevented the use of amoxicillin. The increasingly frequent resistance of Streptococcus pneumoniae and the poor sensitivity of Haemophilus influenzae discourage the use of macrolids; the combination of amoxicillin-clavulanic acid obtained a better score with an efficacy of 89%.
在介绍了他们的研究方法和拭子链的结构后,作者报告了他们暗示的细菌学结果和治疗后果。在这项针对3个月至3岁儿童进行的研究中,无论年龄组如何,流感嗜血杆菌都是最常分离出的细菌。其次是肺炎链球菌和金黄色葡萄球菌。中耳炎的复发性和儿童的生活方式都没有影响流感嗜血杆菌的优势地位。23%的菌株产生β-内酰胺酶。β-内酰胺酶的产生使得阿莫西林无法使用。肺炎链球菌耐药性日益频繁,流感嗜血杆菌敏感性差,这使得大环内酯类药物的使用受到阻碍;阿莫西林-克拉维酸组合的疗效更好,有效率为89%。