Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
School of Industrial Management Engineering, Korea University, Seoul, Republic of Korea.
BMC Infect Dis. 2020 Jul 11;20(1):502. doi: 10.1186/s12879-020-05236-8.
Pregnant women are at high risk of influenza-related morbidity and mortality. In addition, maternal influenza infection may lead to adverse birth outcomes. However, there is insufficient data on long-term impact of maternal influenza infection.
This study was conducted to assess the impact of maternal influenza infection on birth outcomes and long-term influence on infants by merging the Korea National Health Insurance (KNHI) claims database and National Health Screening Program for Infants and Children (NHSP-IC). Mother-offspring pairs were categorized by maternal influenza infection based on the ICD-10 code.
Multivariate analysis revealed that maternal influenza infection significantly increased the risk of preterm birth (OR 1.408) and low birth weight (OR 1.198) irrespective of gestational age. The proportion of low birth weight neonates was significantly higher in influenza-infected women compared to those without influenza. However, since the fourth health screening (30-80 months after birth), the fraction of underweight was no longer different between children from influenza-infected and non-infected mothers, whereas the rates of overweight increased paradoxically in those born to mothers with influenza infection.
Maternal influenza infection might have long-term effects on the health of children and adolescents even after infancy.
孕妇患流感相关疾病的发病率和死亡率很高。此外，母体流感感染可能导致不良的出生结局。然而，关于母体流感感染的长期影响的数据不足。
本研究通过合并韩国国民健康保险（KNHI）理赔数据库和全国婴幼儿健康筛查计划（NHSP-IC），评估母体流感感染对出生结局的影响及其对婴儿的长期影响。根据 ICD-10 编码，将母婴对子按母体流感感染进行分类。
多变量分析显示，母体流感感染显著增加了早产（OR 1.408）和低出生体重（OR 1.198）的风险，而与胎龄无关。与未感染流感的女性相比，感染流感的女性所生的低出生体重儿比例明显更高。然而，自第四次健康筛查（出生后 30-80 个月）以来，来自感染流感母亲的儿童中体重不足的比例不再与未感染流感母亲的儿童有差异，而感染流感母亲所生的儿童超重的比例却反常地增加。
母体流感感染可能对儿童和青少年的健康产生长期影响，甚至在婴儿期之后也是如此。
