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1
Selective cytotoxic activity of immunotoxins composed of a monoclonal anti-Thy 1.1 antibody and the ribosome-inactivating proteins bryodin and momordin.由单克隆抗Thy 1.1抗体与核糖体失活蛋白苔藓抑素和苦瓜素组成的免疫毒素的选择性细胞毒性活性。
Br J Cancer. 1988 Nov;58(5):558-61. doi: 10.1038/bjc.1988.258.
2
An immunotoxin composed of monoclonal anti-Thy 1.1 antibody and a ribosome-inactivating protein from Saponaria officinalis: potent antitumor effects in vitro and in vivo.一种由单克隆抗Thy 1.1抗体和肥皂草核糖体失活蛋白组成的免疫毒素：在体外和体内均具有强大的抗肿瘤作用。
J Natl Cancer Inst. 1985 Jul;75(1):151-9.
3
Comparison of two anti-Thy 1.1-abrin A-chain immunotoxins prepared with different cross-linking agents: antitumor effects, in vivo fate, and tumor cell mutants.两种用不同交联剂制备的抗Thy 1.1-相思子毒素A链免疫毒素的比较：抗肿瘤作用、体内命运及肿瘤细胞突变体
J Natl Cancer Inst. 1987 Nov;79(5):1101-12.
4
Anti-CD30 (BER=H2) immunotoxins containing the type-1 ribosome-inactivating proteins momordin and PAP-S (pokeweed antiviral protein from seeds) display powerful antitumour activity against CD30+ tumour cells in vitro and in SCID mice.含有1型核糖体失活蛋白苦瓜素和PAP-S（来自种子的商陆抗病毒蛋白）的抗CD30（BER=H2）免疫毒素在体外和SCID小鼠体内对CD30+肿瘤细胞显示出强大的抗肿瘤活性。
Br J Haematol. 1996 Mar;92(4):872-9. doi: 10.1046/j.1365-2141.1995.404942.x.
5
Pharmacokinetics in the rat of a panel of immunotoxins made with abrin A chain, ricin A chain, gelonin, and momordin.用相思子毒素A链、蓖麻毒素A链、去甲基金鸡纳碱和苦瓜素制备的一组免疫毒素在大鼠体内的药代动力学。
Cancer Res. 1990 Dec 1;50(23):7519-26.
6
An Epstein-Barr virus-infected lymphoblastoid cell line (D430B) that grows in SCID-mice with the morphologic features of a CD30+ anaplastic large cell lymphoma, and is sensitive to anti-CD30 immunotoxins.一种感染了爱泼斯坦-巴尔病毒的淋巴母细胞系（D430B），它在重症联合免疫缺陷小鼠体内生长，具有CD30 +间变性大细胞淋巴瘤的形态学特征，并且对抗CD30免疫毒素敏感。
Haematologica. 1999 Nov;84(11):988-95.
7
Evaluation of immunotoxins containing single-chain ribosome-inactivating proteins and an anti-CD22 monoclonal antibody (OM124): in vitro and in vivo studies.含单链核糖体失活蛋白和抗CD22单克隆抗体（OM124）的免疫毒素评估：体内外研究
Br J Haematol. 1998 Apr;101(1):179-88. doi: 10.1046/j.1365-2141.1998.00665.x.
8
Purification of immunotoxins containing the ribosome-inactivating proteins gelonin and momordin using high performance liquid immunoaffinity chromatography compared with blue sepharose CL-6B affinity chromatography.与蓝色琼脂糖凝胶CL-6B亲和色谱法相比，使用高效液相免疫亲和色谱法纯化含有核糖体失活蛋白相思豆毒蛋白和苦瓜素的免疫毒素。
J Immunol Methods. 1990 Dec 31;135(1-2):15-24. doi: 10.1016/0022-1759(90)90251-p.
9
Comparison of the selective cytotoxic effects of immunotoxins containing ricin A chain or pokeweed antiviral protein and anti-Thy 1.1 monoclonal antibodies.含蓖麻毒素A链或商陆抗病毒蛋白的免疫毒素与抗Thy 1.1单克隆抗体的选择性细胞毒性作用比较
Cancer Res. 1984 Jan;44(1):201-8.
10
A comparison of anti-lymphocyte immunotoxins containing different ribosome-inactivating proteins and antibodies.含有不同核糖体失活蛋白和抗体的抗淋巴细胞免疫毒素的比较。
Clin Exp Immunol. 1992 Sep;89(3):341-6. doi: 10.1111/j.1365-2249.1992.tb06959.x.

引用本文的文献

1
Hyperuricaemia, Xanthine Oxidoreductase and Ribosome-Inactivating Proteins from Plants: The Contributions of Fiorenzo Stirpe to Frontline Research.高尿酸血症、黄嘌呤氧化还原酶与植物源核糖体失活蛋白：菲奥伦佐·斯特尔佩对前沿研究的贡献
Molecules. 2017 Jan 27;22(2):206. doi: 10.3390/molecules22020206.
2
Immunotoxins constructed with ribosome-inactivating proteins and their enhancers: a lethal cocktail with tumor specific efficacy.免疫毒素由核糖体失活蛋白及其增强子构建：具有肿瘤特异性疗效的致命鸡尾酒。
Curr Pharm Des. 2014;20(42):6584-643. doi: 10.2174/1381612820666140826153913.
3
Tat-mediated delivery of heterologous proteins into cells.Tat介导的异源蛋白向细胞内的递送。
Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):664-8. doi: 10.1073/pnas.91.2.664.
4
An immunotoxin containing momordin suitable for bone marrow purging in multiple myeloma patients.一种含有苦瓜素的免疫毒素，适用于多发性骨髓瘤患者的骨髓净化。
Br J Cancer. 1989 Sep;60(3):315-9. doi: 10.1038/bjc.1989.277.

本文引用的文献

1
Inhibition of protein synthesis in vitro by proteins from the seeds of Momordica charantia (bitter pear melon).苦瓜种子蛋白对体外蛋白质合成的抑制作用。
Biochem J. 1980 Feb 15;186(2):443-52. doi: 10.1042/bj1860443.
2
Immunotoxins: hybrid molecules of monoclonal antibodies and a toxin subunit specifically kill tumour cells.免疫毒素：单克隆抗体与毒素亚基的杂交分子可特异性杀死肿瘤细胞。
Nature. 1981 Mar 12;290(5802):145-6. doi: 10.1038/290145a0.
3
Targeting of the antiviral protein from Phytolacca americana with an antibody.用抗体靶向来自美洲商陆的抗病毒蛋白。
Biochem Biophys Res Commun. 1982 Mar 30;105(2):462-9. doi: 10.1016/0006-291x(82)91457-7.
4
The kinetics of antibody binding to membrane antigens in solution and at the cell surface.抗体与溶液中和细胞表面膜抗原结合的动力学。
Biochem J. 1980 Apr 1;187(1):1-20. doi: 10.1042/bj1870001.
5
Properties of the ribosome-inactivating proteins gelonin, Momordica charantia inhibitor, and dianthins.核糖体失活蛋白（相思子毒素、苦瓜抑制剂和天花粉蛋白）的特性。
Biochem J. 1982 Dec 1;207(3):505-9. doi: 10.1042/bj2070505.
6
Cytotoxicity acquired by conjugation of an anti-Thy1.1 monoclonal antibody and the ribosome-inactivating protein, gelonin.通过抗Thy1.1单克隆抗体与核糖体失活蛋白gelonin偶联获得的细胞毒性。
Eur J Biochem. 1981 Jun 1;116(3):447-54. doi: 10.1111/j.1432-1033.1981.tb05356.x.
7
Properties of immunotoxins against a glycolipid antigen associated with Burkitt's lymphoma.针对与伯基特淋巴瘤相关的糖脂抗原的免疫毒素特性。
Cancer Res. 1984 Jan;44(1):129-33.
8
Prevention of growth of leukemia cells in mice by monoclonal antibodies directed against Thy 1.1 antigen disulfide linked to two ribosomal inhibitors:pokeweed antiviral protein or ricin A chain.通过与两种核糖体抑制剂（商陆抗病毒蛋白或蓖麻毒素A链）二硫键连接的抗Thy 1.1抗原单克隆抗体预防小鼠白血病细胞生长。
Cancer Res. 1984 Apr;44(4):1398-404.
9
Comparison of the selective cytotoxic effects of immunotoxins containing ricin A chain or pokeweed antiviral protein and anti-Thy 1.1 monoclonal antibodies.含蓖麻毒素A链或商陆抗病毒蛋白的免疫毒素与抗Thy 1.1单克隆抗体的选择性细胞毒性作用比较
Cancer Res. 1984 Jan;44(1):201-8.
10
Selective killing of target cells by antibody-ricin A chain or antibody-gelonin hybrid molecules: comparison of cytotoxic potency and use in immunoselection procedures.抗体-蓖麻毒素A链或抗体-去甲氧基鬼臼毒素杂交分子对靶细胞的选择性杀伤：细胞毒性效力比较及其在免疫选择程序中的应用
J Immunol. 1983 Dec;131(6):3091-5.

由单克隆抗Thy 1.1抗体与核糖体失活蛋白苔藓抑素和苦瓜素组成的免疫毒素的选择性细胞毒性活性。

Selective cytotoxic activity of immunotoxins composed of a monoclonal anti-Thy 1.1 antibody and the ribosome-inactivating proteins bryodin and momordin.

作者信息

Stirpe F, Wawrzynczak E J, Brown A N, Knyba R E, Watson G J, Barbieri L, Thorpe P E

机构信息

Dipartimento di Patologia Sperimentale, Universita degli Studi di Bologna, Italy.

出版信息

Br J Cancer. 1988 Nov;58(5):558-61. doi: 10.1038/bjc.1988.258.

DOI:10.1038/bjc.1988.258
PMID:3265330
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2246839/
Abstract

The ribosome-inactivating proteins, bryodin, from Bryonia dioica, and momordin, from Momordica charantia, were coupled by a disulphide bond to a monoclonal anti-Thy 1.1 antibody (OX7). Both immunotoxins were specifically cytotoxic to the Thy 1.1-expressing mouse lymphoma cell line AKR-A in vitro. The OX7-bryodin immunotoxins were the more powerfully toxic and reduced protein synthesis in AKR-A cells by 50% at a concentration of 1-4 x 10(-11) M as compared with 1 x 10(-9) M for the OX7-momordin immunotoxins. Neither of the immunotoxins was toxic to mouse lymphoma EL4 cells, which lack the Thy 1.1 antigen, at concentrations up to 3 x 10(-8) M. Further, bryodin and momordin immunotoxins made from an antibody (R10) of irrelevant specificity were without effect on AKR-A cells.

摘要

来自白泻根的核糖体失活蛋白 bryodin 和来自苦瓜的天花粉蛋白通过二硫键与单克隆抗 Thy 1.1 抗体（OX7）偶联。两种免疫毒素在体外对表达 Thy 1.1 的小鼠淋巴瘤细胞系 AKR-A 均具有特异性细胞毒性。OX7-bryodin 免疫毒素毒性更强，在浓度为 1 - 4×10⁻¹¹ M 时可使 AKR-A 细胞中的蛋白质合成减少 50%，而 OX7-天花粉蛋白免疫毒素则需 1×10⁻⁹ M。在浓度高达 3×10⁻⁸ M 时，两种免疫毒素对缺乏 Thy 1.1 抗原的小鼠淋巴瘤 EL4 细胞均无毒性。此外，由不相关特异性抗体（R10）制备的 bryodin 和天花粉蛋白免疫毒素对 AKR-A 细胞没有影响。