Department of Otolaryngology, Department of Surgery at Santa Casa de Misericórdia of São Paulo and College of Medical Sciences at Santa Casa of SP, São Paulo, Brazil; Skull Base Surgery Center, Santa Casa de São Paulo, São Paulo, Brazil.
Department of Otolaryngology, Department of Surgery at Santa Casa de Misericórdia of São Paulo and College of Medical Sciences at Santa Casa of SP, São Paulo, Brazil.
World Neurosurg. 2020 Oct;142:e337-e343. doi: 10.1016/j.wneu.2020.06.240. Epub 2020 Jul 9.
To determine the impact of endonasal endoscopic access to the skull base on the olfaction sense, involving the harvest of a nasoseptal flap, with the removal of the middle nasal turbinate.
A study was performed on a prospective cohort of 50 patients who underwent transnasal endoscopic surgery of the anterior skull base, with the harvest of a nasoseptal and reverse flap. The patients were divided into 2 groups: partial unilateral removal of the middle nasal turbinate and bilateral removal. Connecticut Chemosensory Clinical Research Center tests were administered before surgery and in months 1, 3, and 6 after surgery.
There was no difference in the olfactory sense, when comparing the partial removal of the middle nasal turbinate and the bilateral removal, as well as when comparing the side without the middle nasal turbinate and the side with this structure preserved. There was a worsening in olfaction (P < 0.001) in months 1 and 3 after surgery, returning to baseline in month 6 (P > 0.05).
Bilateral removal of the middle nasal turbinate, compared with unilateral resection, showed no impact on the olfactory function 6 months after surgery. In both groups, there was a transitory decrease in the first month, but this normalized by the sixth postoperative month.
确定经鼻内镜颅底入路对嗅觉的影响，涉及鼻中隔黏膜瓣的采集，并切除中鼻甲。
对 50 例接受经鼻内镜前颅底手术并采集鼻中隔和反向黏膜瓣的患者进行前瞻性队列研究。患者分为两组：中鼻甲单侧部分切除和双侧切除。在手术前和手术后第 1、3 和 6 个月进行康涅狄格化学感觉临床研究中心测试。
在中鼻甲单侧切除与双侧切除之间，以及在无中鼻甲和保留该结构的一侧之间，嗅觉无差异。术后第 1 和第 3 个月嗅觉恶化（P<0.001），术后第 6 个月恢复基线（P>0.05）。
与单侧切除相比，双侧切除中鼻甲在术后 6 个月对嗅觉功能没有影响。在两组中，第一个月都有短暂的下降，但在术后第 6 个月恢复正常。
