Benetou Christina, Berti Francesco, Hemingway Cheryl, Hacohen Yael, Lim Ming
Department of Children's Neurosciences, Evelina London Children's Hospital, Guys and St. Thomas' Hospital NHS Foundation Trust, Kings Health Partners, London, UK.
Department of Paediatric Neurology, Great Ormond Street Hospital for Children, London, UK.
Mult Scler Relat Disord. 2020 Oct;45:102345. doi: 10.1016/j.msard.2020.102345. Epub 2020 Jun 30.
The neutrophil-to-lymphocyte ratio (NLR) was shown correlate with disease activity in systemic autoimmunity and MS. In a cohort of 62 children with demyelinating diseases; NLR was high both acutely (P<.001) and during remission (P=.01) in AQP4-Ab NMOSD; higher only at time of clinical attack (P<.001) but not at time of remission in MOGAD and not different to that of controls neither during relapse nor remission in MS. The temporal correlation of NLR with MOGAD activity could be used as a supportive biomarker for acute relapse, given that the clinical differentiation between relapses and pseudo-relapses can be challenging.
中性粒细胞与淋巴细胞比值（NLR）已被证明与系统性自身免疫病和多发性硬化症（MS）的疾病活动相关。在一个由62名患有脱髓鞘疾病的儿童组成的队列中；在水通道蛋白4抗体阳性的视神经脊髓炎谱系障碍（AQP4-Ab NMOSD）中，NLR在急性期（P<0.001）和缓解期（P=0.01）均较高；在髓鞘少突胶质细胞糖蛋白抗体相关疾病（MOGAD）中，仅在临床发作时较高（P<0.001），而在缓解期不高，在MS的复发期和缓解期均与对照组无差异。鉴于复发和假性复发之间的临床鉴别可能具有挑战性，NLR与MOGAD活动的时间相关性可作为急性复发的支持性生物标志物。
