Nakayoshi T, Izumi M, Shinkai S, Fujita M
Pharmaceutical Development Laboratories, Meiji Seika Kaisha, Ltd., Kawasaki, Japan.
Drugs Exp Clin Res. 1988;14(5):319-25.
Comparative studies on the effects of 14-membered and 16-membered macrolides on gastrointestinal motility were conducted in unanaesthetized dogs. Midecamycin acetate, a new 16-membered macrolide, and leucomycin, another 16-membered macrolide, did not disturb the gastrointestinal motility and no dogs showed any adverse effects. In contrast, erythromycin stearate, erythromycin ethylsuccinate and triacetyloleandomycin, 14-membered macrolides, caused adverse effects such as strong contractile motility, nausea, vomiting and diarrhoea. The adverse effects of macrolides on the gastrointestinal tract are related to their chemical structure.
在未麻醉的犬身上进行了14元环和16元环大环内酯类药物对胃肠动力影响的比较研究。新的16元环大环内酯类药物醋酸麦迪霉素和另一种16元环大环内酯类药物柱晶白霉素未干扰胃肠动力，且无犬出现任何不良反应。相比之下，14元环大环内酯类药物硬脂酸红霉素、琥乙红霉素和醋竹桃霉素则引起了诸如强烈收缩性蠕动、恶心、呕吐和腹泻等不良反应。大环内酯类药物对胃肠道的不良反应与其化学结构有关。
