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新型杂环体系——Ⅴ. 6H-1,3,4-噻二唑并[3',2':1,2]-5-氧代嘧啶并[5,4-b]吲哚衍生物及1-苯基-6H-1,2,4-三唑并[1',5':1,2]-5-氧代嘧啶并[5,4-b]吲哚的合成与药理活性

New heterocyclic ring systems--V synthesis and pharmacological activity of 6H-1,3,4-thiadiazolo [3',2':1,2]-5-oxopyrimido [5,4-b] indole derivatives and of 1-phenyl-6H-1,2,4-triazolo [1',5':1,2]-5-oxopyrimido[5,4-b] indole.

作者信息

Russo F, Guccione S, Santagati N A, Santagati A, Caruso A, Leone M G, Felice A, Attaguile G, Amico Roxas M

机构信息

Istituto di Chimica Farmaceutica e Tossicologica dell'Università di Catania, Italy.

出版信息

Farmaco Sci. 1988 May;43(5):409-20.

PMID:3265391
Abstract

As a part of a study on analgesic and antiinflammatory active condensed heterocyclic compounds containing the pyrimidinic ring, a number of 6H-1,3,4-thiadiazolo [3',2':1,2]-5-oxopyrimido [5,4-b]indole and 1-phenyl-6H-1,2,4-triazolo [1',5':1,2]-5-oxopyrimido [5,4-b] indole were synthesized and tested. The results of pharmacological assays are reported and discussed.

摘要

作为一项关于含嘧啶环的镇痛和抗炎活性稠合杂环化合物研究的一部分，合成并测试了多种6H-1,3,4-噻二唑并[3',2':1,2]-5-氧代嘧啶并[5,4-b]吲哚和1-苯基-6H-1,2,4-三唑并[1',5':1,2]-5-氧代嘧啶并[5,4-b]吲哚。报告并讨论了药理试验结果。

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