Alanen Julia, Appelblom Heidi, Korpimaki Teemu, Kouru Heikki, Sairanen Mikko, Gissler Mika, Ryynanen Markku, Nevalainen Jaana
Department of Obstetrics and Gynecology, Medical Research Center, PEDEGO Research Unit, University of Oulu and Oulu University Hospital, PL 24, 90100 OYS, Oulu, Finland.
PerkinElmer, Turku, Finland.
Arch Gynecol Obstet. 2020 Oct;302(4):853-860. doi: 10.1007/s00404-020-05670-8. Epub 2020 Jul 11.
To evaluate the performance of first trimester maternal serum glycosylated (Sambucus nigra lectin-reactive) fibronectin in prediction of gestational diabetes mellitus (GDM).
In this case-control study, first trimester maternal serum glycosylated fibronectin and fibronectin were measured in 19 women who consequently developed GDM and in 59 control women with normal pregnancy outcomes. Adiponectin was used as a reference protein to evaluate relation of glycoprotein to SNA-lectin-reactive assay format. Samples were taken during gestational weeks 9-11. Data concerning GDM was obtained from the National Institute for Health and Welfare, which records the pregnancy outcomes of all women in Finland.
There was no difference in maternal serum glycosylated fibronectin concentrations between women with consequent GDM [447.5 μg/mL, interquartile range (IQR) 254.4-540.9 μg/mL] and control women (437.6 μg/mL, IQR 357.1-569.1 μg/mL). Maternal serum fibronectin levels were significantly lower in GDM group (224.2 μg/mL, IQR 156.8-270.6 μg/mL), compared to the control group (264.8 μg/mL, IQR 224.6-330.6 μg/mL, p < 0.01). There was no difference in assay formats for adiponectin.
There was no association between first trimester maternal serum glycosylated (SNA-reactive) fibronectin and GDM.
评估孕早期母体血清糖基化（接骨木凝集素反应性）纤连蛋白在预测妊娠期糖尿病（GDM）中的性能。
在这项病例对照研究中，对19例随后发生GDM的孕妇和59例妊娠结局正常的对照孕妇测定了孕早期母体血清糖基化纤连蛋白和纤连蛋白。脂联素用作参考蛋白，以评估糖蛋白与SNA凝集素反应性检测形式的关系。在妊娠9 - 11周期间采集样本。有关GDM的数据来自国家卫生与福利研究所，该研究所记录了芬兰所有女性的妊娠结局。
随后发生GDM的女性（447.5μg/mL，四分位间距[IQR] 254.4 - 540.9μg/mL）与对照女性（437.6μg/mL，IQR 357.1 - 569.1μg/mL）的母体血清糖基化纤连蛋白浓度无差异。与对照组（264.8μg/mL，IQR 224.6 - 330.6μg/mL，p < 0.01）相比，GDM组的母体血清纤连蛋白水平显著较低（224.2μg/mL，IQR 156.8 - 270.6μg/mL）。脂联素的检测形式无差异。
孕早期母体血清糖基化（SNA反应性）纤连蛋白与GDM之间无关联。
