Department of Orthopaedics, Rutgers New Jersey Medical School, 140 Bergen Street, ACC D1610, Newark, NJ, 07103, USA.
Int Orthop. 2020 Oct;44(10):2147-2153. doi: 10.1007/s00264-020-04707-6. Epub 2020 Jul 11.
Venous thromboembolism (VTE) is a potentially life-threatening condition associated with both orthopaedic surgery and tumour growth. In this study, we identify risk factors associated with VTE in patients with musculoskeletal tumours using two national datasets.
The ACS-NSQIP and NIS databases were queried for patients undergoing surgery with a diagnosis of benign or malignant musculoskeletal tumours. Chi-square and binary logistic regression analyses were used to determine risk factors for VTE.
The incidence of VTE was 2% in both databases. Patients with malignant tumours, those with tumours of the pelvis, sacrum, or coccyx, obesity, arrhythmias, paralysis, metastatic disease, coagulopathy, and recent weight loss were at increased risk for VTE. In patients with benign tumours, those who were African American, those with tumours of the pelvis, sacrum, or coccyx, diabetes, anaemia, and coagulopathy were at increased risk of VTE.
Patients with malignant or benign lesion are at greater risk of VTE if they are age 30 and over, of the African American population, or with tumors of the pelvis/sacrum/coccyx, or any of the following comorbidities: pulmonary disease, paralysis, other neurological disorders, or coagulopathy.
静脉血栓栓塞症（VTE）是一种与骨科手术和肿瘤生长都有关的潜在危及生命的疾病。在这项研究中，我们使用两个国家数据库来确定患有肌肉骨骼肿瘤的患者中与 VTE 相关的风险因素。
在 ACS-NSQIP 和 NIS 数据库中，对接受诊断为良性或恶性肌肉骨骼肿瘤手术的患者进行了查询。使用卡方检验和二项逻辑回归分析来确定 VTE 的风险因素。
在两个数据库中，VTE 的发生率均为 2%。患有恶性肿瘤、骨盆、骶骨或尾骨肿瘤、肥胖、心律失常、瘫痪、转移性疾病、凝血障碍和近期体重减轻的患者，VTE 的风险增加。在患有良性肿瘤的患者中，非洲裔美国人、骨盆、骶骨或尾骨肿瘤、糖尿病、贫血和凝血障碍的患者，VTE 的风险增加。
如果患者年龄在 30 岁及以上、属于非裔美国人，或患有骨盆/骶骨/尾骨肿瘤，或患有以下任何一种合并症：肺部疾病、瘫痪、其他神经疾病或凝血障碍，那么患有恶性或良性病变的患者 VTE 的风险更高。
