Kamal Achmad Fauzi, Ramang Didi Saputra, Prasetyo Marcel
Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia.
Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia.
Adv Orthop. 2021 Feb 19;2021:6678167. doi: 10.1155/2021/6678167. eCollection 2021.
Malignant musculoskeletal tumour may cause considerable burden to general health. The fast growth combined with the tumour characteristics and its invasion capability resulted in the poor prognosis of malignant musculoskeletal tumour. Malignant musculoskeletal tumour may cause significant disability by destroying normal tissue that plays important role in body kinematics. Thromboembolism, including deep vein thrombosis, pulmonary embolism, and other kinds of venous thromboembolism, is one of the most underestimated complications of musculoskeletal tumour. Normally, thrombosis ensues when pathologic factors overcame the body hemostatic regulatory capabilities, which will predispose the body to the formation of thrombus. Venous thromboembolism in musculoskeletal tumour may develop as a result of interaction between the tumour pathologic capabilities and its interaction with normal bodily functions. In this study, we reviewed the burden of musculoskeletal tumour and its complication on global health. Then, the review will focus on the pathologic and clinical aspect of thromboembolism in malignant musculoskeletal tumour, including pathophysiology, diagnosis, and treatment based on recent findings and literature.
恶性肌肉骨骼肿瘤可能给整体健康带来相当大的负担。其快速生长，加上肿瘤特性及其侵袭能力，导致恶性肌肉骨骼肿瘤预后不佳。恶性肌肉骨骼肿瘤可能通过破坏在身体运动学中起重要作用的正常组织而导致严重残疾。血栓栓塞，包括深静脉血栓形成、肺栓塞和其他类型的静脉血栓栓塞，是肌肉骨骼肿瘤最易被低估的并发症之一。通常，当病理因素超过身体止血调节能力时就会发生血栓形成，这会使身体易于形成血栓。肌肉骨骼肿瘤中的静脉血栓栓塞可能是肿瘤病理能力及其与正常身体功能相互作用的结果。在本研究中，我们回顾了肌肉骨骼肿瘤及其并发症对全球健康的负担。然后，本综述将基于近期研究结果和文献，聚焦于恶性肌肉骨骼肿瘤中血栓栓塞的病理和临床方面，包括病理生理学、诊断和治疗。
