Urbano-Ispizua A, Montserrat E, Martí A, Feliu E, Vives-Corrons J L, Rozman C
Postgraduate School of Hematology Farreras-Valentí, Hospital Clínico, Barcelona, Spain.
Nouv Rev Fr Hematol (1978). 1988;30(5-6):325-6.
T lymphocytes and dendritic reticulum cells (DRC) were studied in frozen-cut bone marrow sections of 35 patients with chronic lymphocytic leukemia (CLL) (infiltration patterns: interstitial 8, nodular 6, mixed 9, diffuse 12) and 13 cases of low grade non Hodgkin's lymphoma (NHL) (centroblastic/centrocytic 7, centrocytic 3, lymphoplasmacytoid 3) with bone marrow involvement. In contrast to the usual findings in normal bone marrow, in CLL and low grade NHL CD4 positive cells were more numerous than CD8 positive cells. Whereas in NHL CDR were large and occupied all the nodule, in CLL were small and located in the center of the nodule. These findings can be of interest in the study and differential diagnosis of lymphoproliferative disorders.
对35例慢性淋巴细胞白血病（CLL）（浸润模式：间质型8例、结节型6例、混合型9例、弥漫型12例）及13例有骨髓受累的低级别非霍奇金淋巴瘤（NHL）（中心母细胞/中心细胞型7例、中心细胞型3例、淋巴浆细胞样型3例）的冰冻骨髓切片中的T淋巴细胞和树突状网状细胞（DRC）进行了研究。与正常骨髓中的常见发现相反，在CLL和低级别NHL中，CD4阳性细胞比CD8阳性细胞更多。在NHL中，DRC较大并占据整个结节，而在CLL中，DRC较小且位于结节中心。这些发现可能对淋巴增殖性疾病的研究和鉴别诊断具有意义。
