Lu Bo, Yuan Hui, Zhai Xiaojie, Li Xiaoyu, Qin Jinling, Chen Junping, Meng Bo
Department of Anesthesiology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China.
Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo 315010, China.
Mediators Inflamm. 2020 Jun 19;2020:6983193. doi: 10.1155/2020/6983193. eCollection 2020.
Postoperative cognitive dysfunction (POCD) is a common complication after surgery, especially in aged patients. Neuroinflammation has been closely associated with the development of POCD. While the contribution of pneumoperitoneum to the systemic inflammation has been well documented, the effect of pneumoperitoneal pressure on neuroinflammation and postoperative cognitive function remains unclear. In this study, we showed that high-pressure pneumoperitoneum promoted the postoperative neuroinflammation and microglial activation in the hippocampus and aggravated the postoperative cognitive impairment in aged mice. These results support the requirement to implement interventions with lower intra-abdominal pressure, which allows for adequate exposure of the operative field rather than a routine pressure.
术后认知功能障碍（POCD）是手术后常见的并发症，尤其是在老年患者中。神经炎症与POCD的发生密切相关。虽然气腹对全身炎症的影响已有充分记录，但气腹压力对神经炎症和术后认知功能的影响仍不清楚。在本研究中，我们表明高压气腹促进了老年小鼠海马体中的术后神经炎症和小胶质细胞激活，并加重了术后认知障碍。这些结果支持需要实施较低腹内压的干预措施，以保证手术视野的充分暴露，而不是常规压力。
