Wang Cong-Mei, Chen Wei-Can, Zhang Yan, Lin Shu, He He-Fan
Department of Anesthesiology, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, China.
Diabetes and Metabolism Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia.
Front Aging Neurosci. 2021 Jul 8;13:702231. doi: 10.3389/fnagi.2021.702231. eCollection 2021.
Sevoflurane is one of the most widely used anesthetics for the induction and maintenance of general anesthesia in surgical patients. Sevoflurane treatment may increase the incidence of postoperative cognitive dysfunction (POCD), and patients with POCD exhibit lower cognitive abilities than before the operation. POCD affects the lives of patients and places an additional burden on patients and their families. Understanding the mechanism of sevoflurane-induced POCD may improve prevention and treatment of POCD. In this paper, we review the diagnosis of POCD, introduce animal models of POCD in clinical research, analyze the possible mechanisms of sevoflurane-induced POCD, and summarize advances in treatment for this condition.
七氟醚是外科手术患者全身麻醉诱导和维持过程中使用最广泛的麻醉剂之一。七氟醚治疗可能会增加术后认知功能障碍（POCD）的发生率，患有POCD的患者认知能力低于手术前。POCD影响患者生活，并给患者及其家庭带来额外负担。了解七氟醚诱导POCD的机制可能会改善POCD的防治。在本文中，我们综述了POCD的诊断，介绍了临床研究中的POCD动物模型，分析了七氟醚诱导POCD的可能机制，并总结了针对这种情况的治疗进展。
