Tham S N, Lim J J, Tay S H, Chiew Y F, Chua T N, Tan E, Tan T
Middle Road Hospital, Singapore.
Ann Acad Med Singap. 1988 Oct;17(4):482-5.
410 cases of psoriasis [282 males (68%) and 127 females (31%)] were interviewed and examined to study the nail changes. The prevalence of nail changes was 78.0% (males = females). Common changes were pitting (67.5%) and onycholysis (67.2%). Dystrophy of varying degrees occurred in 35.0%, subungual hyperkeratosis in 24.7%, discoloration in 18.4%, loss of nails in 2.8% and pustulation in 1.3%. Pitting and onycholysis was the most common combination (45.6%). Nail changes were significantly more common in patients who have moderate to severe psoriasis as compared with patients with mild psoriasis; in patients who have psoriasis for greater than 5 years as compared with patients who have psoriasis for less than 5 years; and in patients older than age 50 as compared with those aged less than 50. A definite correlation was found between the prevalence of nail changes and the presence of scalp and periungual psoriasis, and the presence of joint involvement.
对410例银屑病患者[282例男性（68%）和127例女性（31%）]进行了访谈和检查，以研究指甲变化情况。指甲变化的发生率为78.0%（男性 = 女性）。常见变化为点状凹陷（67.5%）和甲剥离（67.2%）。35.0%出现不同程度的甲营养不良，24.7%出现甲下角化过度，18.4%出现变色，2.8%出现指甲缺失，1.3%出现脓疱形成。点状凹陷和甲剥离是最常见的组合（45.6%）。与轻度银屑病患者相比，中度至重度银屑病患者的指甲变化明显更常见；与病程小于5年的银屑病患者相比，病程大于5年的患者指甲变化更常见；与年龄小于50岁的患者相比，年龄大于50岁的患者指甲变化更常见。发现指甲变化的发生率与头皮和甲周银屑病的存在以及关节受累情况之间存在明确的相关性。
