Chutná J, Hasek M, Halán V, Sladecek M
Eur J Immunol. 1977 May;7(5):298-301. doi: 10.1002/eji.1830070511.
Histocompatibility (H) antigens present in the serum of rats induce a relatively high degree of neonatal transplantation tolerance in the absence of cellular chimerism. With the non-H-1 difference, which is relatively strong in the rat strain combination used, skin grafts survive permanently in some animals. With the H-1 plus non-H-1 difference, only some animals show a slight prolongation of skin graft survival, but cytotoxic antibody production is inhibited for long periods of time. In adult animals, at least with the non-H-1 difference, allograft survival is very significantly prolonged after treatment with serum alone, or in combination with hydrocortisone. The nonspecific component(s) of the serum also contributes to a prolongation of graft survival. The data suggest that blood serum is a good source of H antigens which seem to be present in a tolerogenic active form.
大鼠血清中存在的组织相容性（H）抗原在没有细胞嵌合体的情况下可诱导较高程度的新生期移植耐受性。在所使用的大鼠品系组合中，非H-1差异相对较强，一些动物的皮肤移植物可永久存活。对于H-1加非H-1差异，只有一些动物的皮肤移植物存活时间略有延长，但细胞毒性抗体的产生会被长期抑制。在成年动物中，至少对于非H-1差异，单独使用血清或与氢化可的松联合使用后，同种异体移植物的存活时间会非常显著地延长。血清中的非特异性成分也有助于延长移植物的存活时间。数据表明，血清是H抗原的良好来源，这些抗原似乎以致耐受性活性形式存在。
