士的宁会降低海兔和青蛙神经节神经元的电压依赖性钙电流。
Strychnine decreases the voltage-dependent Ca2+ current of both Aplysia and frog ganglion neurons.
作者信息
Oyama Y, Akaike N, Carpenter D O
机构信息
Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201.
出版信息
Cell Mol Neurobiol. 1988 Sep;8(3):307-14. doi: 10.1007/BF00711172.
Abstract
- The effects of strychnine on the voltage-dependent Ca2+ current (ICa) were studied in physically isolated Aplysia neurons and enzymatically dissociated frog sensory neurons of the dorsal root ganglion. Neurons were studied under the internal perfusion and the voltage clamp condition. 2. Strychnine decreased the ICa with threshold concentrations for effect at 1 to 10 microM. The depression of ICa increased with strychnine dose without effects on the current-voltage relation of ICa. The effects of low concentrations of strychnine were reversible, but recovery was incomplete at higher concentrations. The potency of strychnine was about 10 times less than that of diltiazem, an organic Ca2+ antagonist. At 100 microM the ICa of Aplysia neurons was reduced to about half of the control. This concentration of strychnine also reduced the peak amplitude of ICa of frog sensory neurons. 3. These results indicate that, in addition to its actions on transmitter responses and on Na+ and K+ currents, strychnine has effects on ICa that have not previously been appreciated.
摘要
- 在物理分离的海兔神经元和酶解的青蛙背根神经节感觉神经元中研究了士的宁对电压依赖性Ca2+电流（ICa）的影响。在内部灌注和电压钳制条件下对神经元进行研究。2. 士的宁降低ICa，产生效应的阈值浓度为1至10微摩尔。ICa的抑制作用随士的宁剂量增加而增强，且对ICa的电流-电压关系无影响。低浓度士的宁的作用是可逆的，但在较高浓度时恢复不完全。士的宁的效力约为有机Ca2+拮抗剂地尔硫䓬的十分之一。在100微摩尔时，海兔神经元的ICa降至对照的约一半。该浓度的士的宁也降低了青蛙感觉神经元ICa的峰值幅度。3. 这些结果表明，除了对递质反应以及对Na+和K+电流的作用外，士的宁对ICa也有影响，而这一点以前未被认识到。
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