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A novel mutation in /kindlin locus causes distal tip cell migration defects.

作者信息

Park Aileen, Qiu Zhongqiang, Bumm Josh, Lee Myeongwoo

机构信息

Department of Biology, Baylor University, Waco, Texas 76798, United States.

Baylor University Department of Biology.

出版信息

MicroPubl Biol. 2020 Jun 8;2020. doi: 10.17912/micropub.biology.000265.

DOI:10.17912/micropub.biology.000265
PMID:32656510
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7297600/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e0b/7297600/40003709cf25/25789430-2020-micropub.biology.000265.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e0b/7297600/40003709cf25/25789430-2020-micropub.biology.000265.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e0b/7297600/40003709cf25/25789430-2020-micropub.biology.000265.jpg

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The unc-53 gene negatively regulates rac GTPases to inhibit unc-5 activity during Distal tip cell migrations in C. elegans.unc-53 基因负调控 rac GTPases,以抑制线虫远端细胞迁移过程中 unc-5 的活性。
Cell Adh Migr. 2018 May 4;12(3):195-203. doi: 10.1080/19336918.2017.1345413. Epub 2017 Oct 26.
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UNC-52/perlecan affects gonadal leader cell migrations in C. elegans hermaphrodites through alterations in growth factor signaling.UNC-52/基底膜聚糖通过改变生长因子信号传导影响秀丽隐杆线虫雌雄同体性腺引导细胞的迁移。
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引用本文的文献

1
Genetic analysis suggests a surface of PAT-4 (ILK) that interacts with UNC-112 (kindlin).遗传分析表明,PAT-4(整合素连接激酶)的表面与 UNC-112(连接蛋白)相互作用。
G3 (Bethesda). 2022 Jul 6;12(7). doi: 10.1093/g3journal/jkac117.
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Missense mutation of a conserved residue in UNC-112 (kindlin) eliminates binding to PAT-4 (ILK).UNC-112(纽蛋白)中一个保守残基的错义突变消除了与PAT-4(整合素连接激酶)的结合。
MicroPubl Biol. 2021 Sep 14;2021. doi: 10.17912/micropub.biology.000454. eCollection 2021.

本文引用的文献

1
Structural basis of kindlin-mediated integrin recognition and activation.整合素识别和激活的连接蛋白介导作用的结构基础。
Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9349-9354. doi: 10.1073/pnas.1703064114. Epub 2017 Jul 24.
2
High Efficiency, Homology-Directed Genome Editing in Caenorhabditis elegans Using CRISPR-Cas9 Ribonucleoprotein Complexes.利用CRISPR-Cas9核糖核蛋白复合物在秀丽隐杆线虫中进行高效、同源定向基因组编辑
Genetics. 2015 Sep;201(1):47-54. doi: 10.1534/genetics.115.179382. Epub 2015 Jul 17.
3
Quantitative analysis of distal tip cell migration in C. elegans.
Methods Mol Biol. 2009;571:125-36. doi: 10.1007/978-1-60761-198-1_8.
4
Connections between integrins and Rac GTPase pathways control gonad formation and function in C. elegans.整联蛋白与Rac GTP酶途径之间的联系控制线虫的性腺形成和功能。
Biochim Biophys Acta. 2005 May 25;1723(1-3):248-55. doi: 10.1016/j.bbagen.2005.01.003. Epub 2005 Jan 22.
5
Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome.Kindlin-1是秀丽隐杆线虫肌动蛋白-细胞外基质连接蛋白UNC-112的人类同源物,Kindlin-1的缺失会导致Kindler综合征。
Am J Hum Genet. 2003 Jul;73(1):174-87. doi: 10.1086/376609. Epub 2003 Jun 3.
6
Roles for beta(pat-3) integrins in development and function of Caenorhabditis elegans muscles and gonads.β(pat-3)整合素在秀丽隐杆线虫肌肉和性腺发育及功能中的作用。
J Biol Chem. 2001 Sep 28;276(39):36404-10. doi: 10.1074/jbc.M105795200. Epub 2001 Jul 25.
7
The UNC-112 gene in Caenorhabditis elegans encodes a novel component of cell-matrix adhesion structures required for integrin localization in the muscle cell membrane.秀丽隐杆线虫中的UNC-112基因编码一种细胞-基质黏附结构的新组分,该结构是整合素定位于肌细胞膜所必需的。
J Cell Biol. 2000 Jul 10;150(1):253-64. doi: 10.1083/jcb.150.1.253.
8
Genes critical for muscle development and function in Caenorhabditis elegans identified through lethal mutations.通过致死突变鉴定出的秀丽隐杆线虫中对肌肉发育和功能至关重要的基因。
J Cell Biol. 1994 Feb;124(4):475-90. doi: 10.1083/jcb.124.4.475.
9
Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.秀丽隐杆线虫中的高效基因转移:转化序列的染色体外维持与整合
EMBO J. 1991 Dec;10(12):3959-70. doi: 10.1002/j.1460-2075.1991.tb04966.x.