Pettipher E R, Higgs G A, Henderson B
Department of Pharmacology, Wellcome Research Laboratories, Beckenham, Kent.
Dev Biol Stand. 1988;69:111-4.
IL-1 induces PMN and monocyte infiltration when injected into rabbit knee joints (1). This transient synovitis is associated with depletion of proteoglycan from the articular cartilage matrix. However, it is not clear whether the cartilage proteoglycan depletion is dependent on the infiltrating leucocytes. Consequently, we have investigated the effect of intra-articular injection of interleukin-1 in rabbits depleted of circulating PMN and monocytes with nitrogen mustard.
白细胞介素-1注射到兔膝关节时可诱导多形核白细胞（PMN）和单核细胞浸润（1）。这种短暂性滑膜炎与关节软骨基质中蛋白聚糖的消耗有关。然而，尚不清楚软骨蛋白聚糖的消耗是否依赖于浸润的白细胞。因此，我们研究了用氮芥清除循环中的PMN和单核细胞的兔关节内注射白细胞介素-1的效果。
