Banik Soumyabrata, Mahato Krishna K, Antonini Andrea, Mazumder Nirmal
Department of Biophysics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genoa, Italy.
Microsc Res Tech. 2020 Nov;83(11):1336-1344. doi: 10.1002/jemt.23525. Epub 2020 Jul 12.
Many diseases in rural areas and developing countries are detected late at an advanced stage when treatment might involve complications and higher cost, resulting in a greater number of fatalities. This study aims to make early disease detection simpler and affordable for people living in remote areas and developing countries. A new age optical microscope with high sensitivity diagnosis can revolutionize this gap in disease detection. Here, a smartphone-based imaging device (SID) using optics and a smartphone interface was developed to speedup the process of diagnosis in areas that do not have easy access to health centers and diagnostic clinics. The device was built using acrylic sheets to make it less bulky and customizable and three-dimensional (3D) printed mechanical parts were used to increase stability. The study includes calibration, and testing the device with various samples to determine its capabilities. Images were acquired using the various types of BLIPS lens integrated onto the smartphone camera lens and compared with optical microscope images. The device can visualize single human blood cell which is 8 μm in size using ultra-BLIPS lens and magnification is comparable to an objective lens used in an optical microscope.
农村地区和发展中国家的许多疾病在晚期才被发现，此时治疗可能会出现并发症且成本更高，从而导致更多人死亡。本研究旨在让偏远地区和发展中国家的人们能够更简便、更经济地进行疾病早期检测。一种具有高灵敏度诊断功能的新型光学显微镜可以彻底改变疾病检测方面的这一差距。在此，开发了一种基于智能手机的成像设备（SID），它利用光学原理和智能手机界面，以加快在难以前往健康中心和诊断诊所的地区的诊断过程。该设备使用丙烯酸板制造，使其体积更小且可定制，还使用了三维（3D）打印的机械部件来提高稳定性。该研究包括校准，并使用各种样本对设备进行测试以确定其性能。使用集成到智能手机相机镜头上的各种类型的BLIPS镜头采集图像，并与光学显微镜图像进行比较。该设备使用超BLIPS镜头可以可视化大小为8微米的单个人类血细胞，其放大倍数与光学显微镜中使用的物镜相当。
