From the Department of Paediatric Infectious Diseases & Immunology, Evelina London Children's Hospital, Guy's and St. Thomas' NHS Foundation Trust, London.
National Infection Service, Public Health England, London.
Pediatr Infect Dis J. 2020 Sep;39(9):e257-e260. doi: 10.1097/INF.0000000000002821.
To date, although neonatal infections with severe acute respiratory syndrome coronovirus 2 (SARS-CoV-2) have been described, none of these have been proven to be the result of vertical transmission of SARS-CoV-2.
We describe the probable vertical transmission of SARS-CoV-2 in a neonate born to a mother with coronavirus disease 2019 (COVID-19).
Following cesarean section, the neonate was kept in strict isolation. Molecular tests for SARS-CoV-2 on respiratory samples, blood, and meconium were initially negative, but positive on a nasopharyngeal aspirate on the third day of life. On day 5, the neonate developed fever and coryza, which spontaneously resolved. Viral genomic analysis from the mother and neonate showed identical sequences except for 1 nucleotide.
This report has important implications for infection control and clinical management of pregnant women with COVID-19 and their newborns.
迄今为止，虽然已经描述了新生儿感染严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的情况，但尚无证据表明这些感染是 SARS-CoV-2 垂直传播的结果。
我们描述了一例由患有 2019 年冠状病毒病（COVID-19）的母亲分娩的新生儿中 SARS-CoV-2 可能的垂直传播。
剖宫产术后，新生儿被严格隔离。对呼吸道样本、血液和胎便进行的 SARS-CoV-2 分子检测最初均为阴性，但在出生后第 3 天的鼻咽抽吸物中呈阳性。第 5 天，新生儿出现发热和鼻咽炎，自行缓解。来自母亲和新生儿的病毒基因组分析显示除 1 个核苷酸外序列完全相同。
本报告对感染控制以及 COVID-19 孕妇及其新生儿的临床管理具有重要意义。
