Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California.
Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California; and.
Retina. 2020 Nov;40(11):2106-2112. doi: 10.1097/IAE.0000000000002878.
To quantify the regional variation in choriocapillaris (CC) flow deficits percentage (FD%) surrounding treatment-naïve Type 1 choroidal neovascularization (CNV) associated with age-related macular degeneration.
Patients were imaged with swept-source optical coherence tomography angiography system (Carl Zeiss PLEX Elite 9000; Carl Zeiss Meditec AG, Jena, Germany). Two 6 × 6-mm volume scans were acquired. Boundary-specific segmentation was used to isolate the Type 1 CNV. For CC assessment, both structural and optical coherence tomography angiography CC slabs (10-µm thick, starting 21 µm below the retinal pigment epithelium fit reference) were exported for signal compensation and averaging using ImageJ. The resultant CC image was binarized to calculate the FD%, for para-CNV and peri-CNV rings (each 500-µm wide). In a subgroup of 20 eyes, the FD% was compared with similar regions of age-matched controls. The FD% was also analyzed in small 500 × 500-µm squares equidistant from the fovea to compensate for regional variation of CC FD% as a potential confounding factor.
Thirty-two eyes from 27 subjects were enrolled in this study. The CC FD% in the para-CNV ring was 26.58 ± 7.36, which was significantly higher than the peri-CNV ring (21.94 ± 6.31); P < 0.001. The FD% in para-CNV and peri-CNV rings was significantly greater than that of healthy controls (15.82 ± 1.29% and 15.53 ± 1.32%, respectively); P < 0.001. The FD% computed in the 500-µm squares equidistant from the fovea was also greater in the para-CNV ring (26.14 ± 7.11) than that in the peri-CNV ring (22.31 ± 6.21); P < 0.001.
Choriocapillaris FD% is the highest in the region immediately surrounding the CNV.
定量评估与年龄相关性黄斑变性相关的未经治疗的 1 型脉络膜新生血管（CNV）周围脉络膜毛细血管（CC）血流缺损百分比（FD%）的区域性变化。
使用扫频源光学相干断层扫描血管造影系统（Carl Zeiss PLEX Elite 9000；Carl Zeiss Meditec AG，耶拿，德国）对患者进行成像。采集两个 6×6mm 的体积扫描。采用边界特异性分割方法来分离 1 型 CNV。为了评估 CC，从视网膜色素上皮下方 21μm 处开始导出结构和光相干断层扫描血管造影 CC 切片（10μm 厚），以使用 ImageJ 进行信号补偿和平均处理。将生成的 CC 图像二值化以计算 FD%，用于旁 CNV 和周 CNV 环（每个 500μm 宽）。在 20 只眼睛的亚组中，将 FD%与年龄匹配的对照组的相似区域进行比较。还在距黄斑等距离的 500×500μm 的小正方形中分析 FD%，以补偿 CC FD%的区域性变化，作为潜在的混杂因素。
这项研究共纳入了 27 名受试者的 32 只眼睛。旁 CNV 环的 CC FD%为 26.58±7.36，明显高于周 CNV 环（21.94±6.31）；P<0.001。旁 CNV 和周 CNV 环的 FD%明显高于健康对照组（分别为 15.82±1.29%和 15.53±1.32%）；P<0.001。距黄斑等距离的 500μm 正方形中的 FD%在旁 CNV 环中（26.14±7.11）也高于周 CNV 环（22.31±6.21）；P<0.001。
CNV 周围区域的脉络膜毛细血管 FD%最高。
