Retina Disorders and Ophthalmic Genetics, Stein Eye Institute, University of California-Los Angeles, Los Angeles, California, United States.
Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, United States.
Invest Ophthalmol Vis Sci. 2020 Sep 1;61(11):11. doi: 10.1167/iovs.61.11.11.
To evaluate choriocapillaris (CC) flow deficits (FD) in eyes with treatment-naïve macular neovascularization (MNV) and to compare CC FD around exudative versus nonexudative MNV.
Treatment-naïve eyes with a diagnosis of either exudative or nonexudative AMD and type 1 MNV were included. Normal control eyes were age-matched to each AMD eye one to one. En face optical coherence tomography angiograms were analyzed for percentage of CC FD (FD%) in two concentric 500 µm rings, ring 1 and ring 2, surrounding the dark halo around MNV. The mean CC FD% in ring 1 and ring 2 was evaluated for each eye. A secondary analysis was similarly carried out to investigate the differences in CC FD% in exudative versus nonexudative treatment-naïve MNV.
Twenty-three eyes with treatment-naïve MNV were age matched with 23 normal controls. The mean CC FD% was significantly greater in both rings in the MNV versus the normal control group (P < 0.05) and was significantly greater in the inner ring, closer to the lesion, than the outer ring. The mean FD% was also greater in both rings in the exudative versus the nonexudative MNV group, but this difference did not reach statistical significance.
The CC FD% was greater in the area surrounding MNV versus age-matched normal controls and in the ring closer to the MNV lesion. Further, CC FD was greater in eyes with exudative versus nonexudative MNV in both rings surrounding the associated dark halo, although this difference was not statistically significant.
评估未经治疗的黄斑新生血管（MNV）患者脉络膜毛细血管（CC）血流缺损（FD），并比较渗出性与非渗出性 MNV 周围的 CC FD。
纳入诊断为渗出性或非渗出性 AMD 且伴有 1 型 MNV 的未经治疗的患者。正常对照眼与每位 AMD 眼一一配对。对视盘周围 OCT 血管造影中 MNV 暗晕周围的两个同心 500µm 环（环 1 和环 2）进行 CC FD（FD%）的百分比分析。评估每个眼的环 1 和环 2 中的平均 CC FD%。同样进行了二次分析，以研究渗出性与非渗出性未经治疗的 MNV 之间 CC FD%的差异。
23 只未经治疗的 MNV 眼与 23 只正常对照眼进行了年龄匹配。MNV 组的 CC FD%在两个环中均明显大于正常对照组（P<0.05），且内环（更靠近病变）大于外环。渗出性 MNV 组的两个环的平均 FD%也均大于非渗出性 MNV 组，但差异无统计学意义。
MNV 周围区域的 CC FD%大于年龄匹配的正常对照组，且内环（更靠近病变）大于外环。此外，在围绕相关暗晕的两个环中，渗出性 MNV 眼的 CC FD 大于非渗出性 MNV 眼，尽管这种差异无统计学意义。
