绝经后时期维生素D与血管舒缩症状之间的关系。

The Relationship between Vitamin D and Vasomotor Symptoms During the Postmenopausal Period.

作者信息

Arslanca Tufan, Korkmaz Hilal, Arslanca S Banu, Pehlivanoglu Bilge, Celikel Özgül

出版信息

Clin Lab. 2020 Jul 1;66(7). doi: 10.7754/Clin.Lab.2019.191116.

DOI:10.7754/Clin.Lab.2019.191116

PMID:32658424

Abstract

BACKGROUND

During the postmenopausal period, hot flashes are frequent symptoms and might impact quality of life. Vitamin D deficiency is commonly seen in this period. This study aims to assess the association between vitamin D deficiency and hot flashes.

METHODS

Two hundred ten postmenopausal women were recruited. The participants were divided into two groups: Group 1 consisted of postmenopausal women with hot flashes (n = 104), and Group 2 included the participants without hot flashes (n = 106).

RESULTS

The comparison of the two groups concerning vitamin D level showed that 52 patients Group 1 had vitamin 25(OH)D levels below 20 ng/mL, whereas only 25 patients in Group 2 (p < 0.001). After adjusting for age and menopause duration, there was also a significant difference between groups (21.65 vs. 34.17, respectively, p < 0.001). In multiple regression analysis, one unit decrease of vitamin 25(OH)D (1 - 0.941 = 0.059) increased the risk of hot flashes by 5.9%.

CONCLUSIONS

The decreases of vitamin D levels were significantly associated with hot flashes in postmenopausal women independent of age and menopause duration.

摘要

背景

在绝经后时期，潮热是常见症状，可能会影响生活质量。维生素D缺乏在这一时期很常见。本研究旨在评估维生素D缺乏与潮热之间的关联。

方法

招募了210名绝经后女性。参与者被分为两组：第1组由有潮热的绝经后女性组成（n = 104），第2组包括没有潮热的参与者（n = 106）。

结果

两组维生素D水平的比较显示，第1组有52例患者的25(OH)D水平低于20 ng/mL，而第2组只有25例患者（p < 0.001）。在调整年龄和绝经持续时间后，两组之间也存在显著差异（分别为21.65和34.17，p < 0.001）。在多元回归分析中，25(OH)D每降低一个单位（1 - 0.941 = 0.059），潮热风险增加5.9%。