Laboratory of Drug and Gene Delivery Research, Faculty of Pharma-Science, Teikyo University, Tokyo, Japan.
Laboratory of Theranostics, Faculty of Pharma-Science, Teikyo University, Tokyo, Japan.
Adv Drug Deliv Rev. 2020;154-155:236-244. doi: 10.1016/j.addr.2020.07.005. Epub 2020 Jul 10.
Microbubbles with diagnostic ultrasound have had a long history of use in the medical field. In recent years, the therapeutic application of the combination of microbubbles and ultrasound, called sonoporation, has received increased attention as microbubble oscillation or collapse close to various barriers in the body was recognized to potentially open those barriers, increasing drug transport across them. In this review, we aimed to describe the development of lipid-stabilized microbubbles equipped with functions, such as long circulation and drug loading, and the therapeutic application of sonoporation for tumor-targeted therapy, brain-targeted therapy, and immunotherapy. We also attempted to discuss the current status of the field and potential future developments.
带有诊断超声的微泡在医学领域有着悠久的应用历史。近年来，微泡与超声联合的治疗应用，即声孔效应，作为一种潜在的增加药物跨膜转运的方法，已受到越来越多的关注，因为人们认识到微泡在接近体内各种屏障时的振动或崩溃可能会打开这些屏障。在这篇综述中，我们旨在描述功能化的脂质稳定微泡的发展，如长循环和载药功能，以及声孔效应在肿瘤靶向治疗、脑靶向治疗和免疫治疗中的治疗应用。我们还试图讨论该领域的现状和潜在的未来发展。
