Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150. China.
Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, No. 101, Kuang-Fu Road, Hsinchu, 30013. Taiwan.
Curr Pharm Des. 2017;23(23):3383-3390. doi: 10.2174/1381612823666170113092148.
Ultrasound microbubbles have conventionally been used for diagnostic purposes. In recent years, however, new types of microbubbles have emerged as important carriers for drug delivery. Moreover, studies have shown that ultrasound microbubbles can serve as valuable and noninvasive tools in cancer therapy; thus the use of ultrasound microbubbles to deliver chemotherapeutic drugs to malignant tissues is a promising possibility.
In this review, we briefly describe the status of ultrasound microbubbles in clinical practice and then discuss the development of targeted microbubbles. Finally, we consider novel strategies for the use of microbubbles in cancer therapy.
Many different kinds of microbubbles are emerged. Novel strategies of ultrasound microbubble have been shown to be effective in cancer therapy.
Although many problems need to be solved in the future, the ultrasound drugs loaded microbubbles still have strong potential for the use in clinical cancer therapy.
超声微泡传统上被用于诊断目的。然而，近年来，新型微泡已成为药物输送的重要载体。此外，研究表明，超声微泡可用作癌症治疗中有价值的非侵入性工具；因此，使用超声微泡将化疗药物递送到恶性组织是一种很有前途的可能性。
在本综述中，我们简要描述了超声微泡在临床实践中的现状，然后讨论了靶向微泡的发展。最后，我们考虑了微泡在癌症治疗中的新策略。
已经出现了许多不同类型的微泡。超声微泡的新策略已被证明对癌症治疗有效。
尽管未来还需要解决许多问题，但载药超声微泡在临床癌症治疗中仍具有很强的应用潜力。
